Journal article
Basolateral amygdala projections to ventral hippocampus modulate the consolidation of footshock, but not contextual, learning in rats
Learning & memory (Cold Spring Harbor, N.Y.), Vol.23(2), pp.51-60
02/2016
DOI: 10.1101/lm.039909.115
PMCID: PMC4749832
PMID: 26773098
Abstract
The basolateral amygdala (BLA) modulates memory consolidation for a variety of types of learning, whereas other brain regions play more selective roles in specific kinds of learning suggesting a role for differential consolidation via distinct BLA pathways. The ventral hippocampus (VH), an efferent target of the BLA, has been suggested to selectively process emotion-related learning, yet whether the BLA → VH pathway modulates memory consolidation, and does so in a learning-specific manner, is unknown. To address this issue, the BLA of male Sprague-Dawley rats was bilaterally transduced to express either ChR2(E123A) or eArchT3.0. Fiber optic probes were implanted in the VH to provide illumination of BLA axons. Rats then underwent a modified contextual fear conditioning task permitting separation of context and footshock learning. On day 1, rats received 3 min of pre-exposure to the apparatus. On day 2, rats were placed into the apparatus, received an immediate footshock, and quickly removed. Retention was tested on day 4. Optical stimulation of the BLA → VH pathway following footshock, but not context, training using trains of 40-Hz light pulses enhanced retention. Continuous optical inhibition of this pathway for 15 min starting 25 min after footshock training impaired retention. These findings indicate that BLA → VH projections influence the consolidation for footshock, but not context, learning of a modified CFC task and provide direct evidence that BLA projections to other brain regions modulate memory consolidation selectively depending on the kind of learning involved.
Details
- Title: Subtitle
- Basolateral amygdala projections to ventral hippocampus modulate the consolidation of footshock, but not contextual, learning in rats
- Creators
- Mary L Huff - Department of Psychological and Brain Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA mary-l-huff@uiowa.eduEric B Emmons - Interdisciplinary Graduate Program in Neuroscience, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USANandakumar S Narayanan - Interdisciplinary Graduate Program in Neuroscience, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USARyan T LaLumiere - Department of Psychological and Brain Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA Interdisciplinary Graduate Program in Neuroscience, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
- Resource Type
- Journal article
- Publication Details
- Learning & memory (Cold Spring Harbor, N.Y.), Vol.23(2), pp.51-60
- DOI
- 10.1101/lm.039909.115
- PMID
- 26773098
- PMCID
- PMC4749832
- NLM abbreviation
- Learn Mem
- ISSN
- 1072-0502
- eISSN
- 1549-5485
- Publisher
- United States
- Grant note
- R01 NS089470 / NINDS NIH HHS F31 MH105187 / NIMH NIH HHS R01 MH104384 / NIMH NIH HHS MH105187 / NIMH NIH HHS T32 GM108540 / NIGMS NIH HHS R21 MH097111 / NIMH NIH HHS MH104384 / NIMH NIH HHS MH097111 / NIMH NIH HHS
- Language
- English
- Date published
- 02/2016
- Academic Unit
- Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002343602771
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