Journal article
Battle for Metals: Regulatory RNAs at the Front Line
Frontiers in cellular and infection microbiology, Vol.12, pp.952948-952948
07/05/2022
DOI: 10.3389/fcimb.2022.952948
PMCID: PMC9294342
PMID: 35865816
Abstract
Metal such as iron, zinc, manganese, and nickel are essential elements for bacteria. These nutrients are required in crucial structural and catalytic roles in biological processes, including precursor biosynthesis, DNA replication, transcription, respiration, and oxidative stress responses. While essential, in excess these nutrients can also be toxic. The immune system leverages both of these facets, to limit bacterial proliferation and combat invaders. Metal binding immune proteins reduce the bioavailability of metals at the infection sites starving intruders, while immune cells intoxicate pathogens by providing metals in excess leading to enzyme mismetallation and/or reactive oxygen species generation. In this dynamic metal environment, maintaining metal homeostasis is a critical process that must be precisely coordinated. To achieve this, bacteria utilize diverse metal uptake and efflux systems controlled by metalloregulatory proteins. Recently, small regulatory RNAs (sRNAs) have been revealed to be critical post-transcriptional regulators, working in conjunction with transcription factors to promote rapid adaptation and to fine-tune bacterial adaptation to metal abundance. In this mini review, we discuss the expanding role for sRNAs in iron homeostasis, but also in orchestrating adaptation to the availability of other metals like manganese and nickel. Furthermore, we describe the sRNA-mediated interdependency between metal homeostasis and oxidative stress responses, and how regulatory networks controlled by sRNAs contribute to survival and virulence.
Details
- Title: Subtitle
- Battle for Metals: Regulatory RNAs at the Front Line
- Creators
- Mathilde Charbonnier - Architecture et Réactivité de l'arNGabriela Gonzalez-Espinoza - Architecture et Réactivité de l'arNThomas E. Kehl-Fie - University of Illinois Urbana-ChampaignDavid Lalaouna - Architecture et Réactivité de l'arN
- Resource Type
- Journal article
- Publication Details
- Frontiers in cellular and infection microbiology, Vol.12, pp.952948-952948
- Publisher
- Frontiers Media Sa
- DOI
- 10.3389/fcimb.2022.952948
- PMID
- 35865816
- PMCID
- PMC9294342
- ISSN
- 2235-2988
- eISSN
- 2235-2988
- Number of pages
- 8
- Grant note
- Thomas Jefferson Fund, a program of FACE Foundation ANR-20-CE12-0021 / Agence Nationale de la Recherche; Agence Nationale de la Recherche (ANR) ANR-17-EURE-0023 / EUR IMCBio R01AI155611; R21AI149115 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA ANR 20-SFRI-0012 / SFRI-STRAT'US project ANR-10-IDEX-0002 / IdEx Unistra ANR-10-LABX-0036 / Labex NetRNA ED414 / Ecole Doctorale des Sciences de la Vie et de la Sante
- Language
- English
- Date published
- 07/05/2022
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984618521202771
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