Bax-deficient mice with lymphoid hyperplasia and male germ cell death

C. M KNUDSON; K. S. K TUNG; W. G TOURTELOTTE; G. A. J BROWN; S. J KORSMEYER

doi:10.1126/science.270.5233.96

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Bax-deficient mice with lymphoid hyperplasia and male germ cell death

Journal article

Peer reviewed

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

C. M KNUDSON, K. S. K TUNG, W. G TOURTELOTTE, G. A. J BROWN and S. J KORSMEYER

Science (American Association for the Advancement of Science), Vol.270(5233), pp.96-99

1995

DOI: 10.1126/science.270.5233.96

PMID: 7569956

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Abstract

BAX, a heterodimeric partner of BCL2, counters BCL2 and promotes apoptosis in gain-of-function experiments. A Bax knockout mouse was generated that proved viable but displayed lineage-specific aberrations in cell death. Thymocytes and B cells in this mouse displayed hyperplasia, and Bax-deficient ovaries contained unusual atretic follicles with excess granulosa cells. In contrast, Bax-deficient males were infertile as a result of disordered seminiferous tubules with an accumulation of atypical premeiotic germ cells, but no mature haploid sperm. Multinucleated giant cells and dysplastic cells accompanied massive cell death. Thus, the loss of Bax results in hyperplasia or hypoplasia, depending on the cellular context.

Fundamental and applied biological sciences. Psychology

Classical genetics, quantitative genetics, hybrids

Biological and medical sciences

Vertebrata

Animals

Genetics of eukaryotes. Biological and molecular evolution

Details

Title: Subtitle: Bax-deficient mice with lymphoid hyperplasia and male germ cell death
Creators: C. M KNUDSON - Washington univ. school medicine, Howard Hughes medical inst. and div. molecular oncology, St. Louis MO 63110, United States
K. S. K TUNG - Washington univ. school medicine, Howard Hughes medical inst. and div. molecular oncology, St. Louis MO 63110, United States
W. G TOURTELOTTE - Washington univ. school medicine, Howard Hughes medical inst. and div. molecular oncology, St. Louis MO 63110, United States
G. A. J BROWN - Washington univ. school medicine, Howard Hughes medical inst. and div. molecular oncology, St. Louis MO 63110, United States
S. J KORSMEYER - Washington univ. school medicine, Howard Hughes medical inst. and div. molecular oncology, St. Louis MO 63110, United States
Resource Type: Journal article
Publication Details: Science (American Association for the Advancement of Science), Vol.270(5233), pp.96-99
Publisher: American Association for the Advancement of Science; Washington, DC
DOI: 10.1126/science.270.5233.96
PMID: 7569956
ISSN: 0036-8075
eISSN: 1095-9203
Language: English
Date published: 1995
Academic Unit: Pathology; Radiation Oncology
Record Identifier: 9984046912502771

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