Journal article
Bcl-2 and Bax function independently to regulate cell death
Nature genetics, Vol.16(4), pp.358-363
08/1997
DOI: 10.1038/ng0897-358
PMID: 9241272
Abstract
The BCL-2 family has various pairs of antagonist and agonist proteins that regulate apoptosis. Whether their function is interdependent is uncertain. Using a genetic approach to address this question, we utilized gain- and loss-of-function models of Bcl-2 and Bax and found that apoptosis and thymic hypoplasia characteristic of Bcl-2-deficient mice are largely absent in mice also deficient in Bax. A single copy of Bax promoted apoptosis in the absence of Bcl-2. In contrast, overexpression of Bcl-2 still repressed apoptosis in the absence of Bax. While an in vivo competition exists between Bax and Bcl-2, each is able to regulate apoptosis independently.
Details
- Title: Subtitle
- Bcl-2 and Bax function independently to regulate cell death
- Creators
- C. Michael KnudsonStanley J Korsmeyer
- Resource Type
- Journal article
- Publication Details
- Nature genetics, Vol.16(4), pp.358-363
- DOI
- 10.1038/ng0897-358
- PMID
- 9241272
- ISSN
- 1061-4036
- eISSN
- 1546-1718
- Language
- English
- Date published
- 08/1997
- Academic Unit
- Pathology; Radiation Oncology
- Record Identifier
- 9984047991502771
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