Journal article
Bed nuclei of the stria terminalis modulate memory consolidation via glucocorticoid-dependent and -independent circuits
Proceedings of the National Academy of Sciences - PNAS, Vol.117(14), pp.8104-8114
04/07/2020
DOI: 10.1073/pnas.1915501117
PMCID: PMC7148582
PMID: 32193346
Abstract
There is extensive evidence that glucocorticoid hormones enhance memory consolidation, helping to ensure that emotionally significant events are well remembered. Prior findings suggest that the anteroventral region of bed nuclei of the stria terminalis (avBST) regulates glucocorticoid release, suggesting the potential for avBST activity to influence memory consolidation following an emotionally arousing learning event. To investigate this issue, male Sprague-Dawley rats underwent inhibitory avoidance training and repeated measurement of stress hormones, immediately followed by optogenetic manipulations of either the avBST or its projections to downstream regions, and 48 h later were tested for retention. The results indicate that avBST inhibition augmented posttraining pituitary-adrenal output and enhanced the memory for inhibitory avoidance training. Pretreatment with a glucocorticoid synthesis inhibitor blocked the memory enhancement as well as the potentiated corticosterone response, indicating the dependence of the memory enhancement on glucocorticoid release during the immediate posttraining period. In contrast, posttraining avBST stimulation decreased retention yet had no effect on stress hormonal output. Subsequent experiments revealed that inhibition of avBST input to the paraventricular hypothalamus enhanced stress hormonal output and subsequent retention, whereas stimulation did not affect either. Conversely, stimulation-but not inhibition-of avBST input to the ventrolateral periaqueductal gray impaired consolidation, whereas neither manipulation affected glucocorticoid secretion. These findings indicate that divergent pathways from the avBST are responsible for the mnemonic effects of avBST inhibition versus stimulation and do so via glucocorticoid-dependent and -independent mechanisms, respectively.
Details
- Title: Subtitle
- Bed nuclei of the stria terminalis modulate memory consolidation via glucocorticoid-dependent and -independent circuits
- Creators
- Ryan T Lingg - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242Shane B Johnson - Interdisciplinary Neuroscience Program, University of Iowa, Iowa City, IA 52242Eric B Emmons - Interdisciplinary Neuroscience Program, University of Iowa, Iowa City, IA 52242Rachel M Anderson - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242Sara A Romig-Martin - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242Nandakumar S Narayanan - Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242James L McGaugh - Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800Ryan T LaLumiere - Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242Jason J Radley - Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242
- Resource Type
- Journal article
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.117(14), pp.8104-8114
- DOI
- 10.1073/pnas.1915501117
- PMID
- 32193346
- PMCID
- PMC7148582
- NLM abbreviation
- Proc Natl Acad Sci U S A
- ISSN
- 0027-8424
- eISSN
- 1091-6490
- Publisher
- National Academy of Sciences; United States
- Grant note
- R01 MH119106 / NIMH NIH HHS R56 MH095972 / NIMH NIH HHS
- Language
- English
- Date published
- 04/07/2020
- Academic Unit
- Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984070322102771
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