Journal article
Behavior Profiles at 2 Years for Children Born Extremely Preterm with Bronchopulmonary Dysplasia
The Journal of pediatrics, Vol.219, pp.152-159.e5
04/01/2020
DOI: 10.1016/j.jpeds.2019.12.028
PMCID: PMC7096270
PMID: 32008764
Abstract
Objective To characterize behavior of 2-year-old children based on the severity of bronchopulmonary dysplasia (BPD).
Study design We studied children born at 22-26 weeks of gestation and assessed at 22-26 months of corrected age with the Child Behavior Checklist (CBCL). BPD was classified by the level of respiratory support at 36 weeks of postmenstrual age. CBCL syndrome scales were the primary outcomes. The relationship between BPD grade and behavior was evaluated, adjusting for perinatal confounders. Mediation analysis was performed to evaluate whether cognitive, language, or motor skills mediated the effect of BPD grade on behavior.
Results Of 2310 children, 1208 (52%) had no BPD, 806 (35%) had grade 1 BPD, 177 (8%) had grade 2 BPD, and 119 (5%) had grade 3 BPD. Withdrawn behavior (P < .001) and pervasive developmental problems (P < .001) increased with worsening BPD grade. Sleep problems (P = .008) and aggressive behavior (P = .023) decreased with worsening BPD grade. Children with grade 3 BPD scored 2 points worse for withdrawn behavior and pervasive developmental problems and 2 points better for externalizing problems, sleep problems, and aggressive behavior than children without BPD. Cognitive, language, and motor skills mediated the effect of BPD grade on the attention problems, emotionally reactive, somatic complaints, and withdrawn CBCL syndrome scales (P values < .05).
Conclusions BPD grade was associated with increased risk of withdrawn behavior and pervasive developmental problems but with decreased risk of sleep problems and aggressive behavior. The relationship between BPD and behavior is complex. Cognitive, language, and motor skills mediate the effects of BPD grade on some problem behaviors.
Details
- Title: Subtitle
- Behavior Profiles at 2 Years for Children Born Extremely Preterm with Bronchopulmonary Dysplasia
- Creators
- Jane E. Brumbaugh - Mayo Clinic in FloridaEdward F. Bell - University of IowaScott F. Grey - RTI InternationalSara B. DeMauro - University of PennsylvaniaBetty R. Vohr - Brown UniversityHeidi M. Harmon - University of IowaCarla M. Bann - Research Triangle Park FoundationMatthew A. Rysavy - University of IowaJ. Wells Logan - The Ohio State UniversityTarah T. Colaizy - University of IowaMyriam A. Peralta-Carcelen - University of Alabama at BirminghamElisabeth C. McGowan - Brown UniversityAndrea F. Duncan - The University of Texas Health Science Center at HoustonBarbara J. Stoll - The University of Texas Health Science Center at HoustonAbhik Das - RTI InternationalSusan R. Hintz - Stanford UniversityEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
- Contributors
- John M Dagle (Contributor) - University of Iowa, Stead Family Department of Pediatrics
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.219, pp.152-159.e5
- DOI
- 10.1016/j.jpeds.2019.12.028
- PMID
- 32008764
- PMCID
- PMC7096270
- NLM abbreviation
- J Pediatr
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Publisher
- Elsevier
- Number of pages
- 14
- Grant note
- Eunice Kennedy Shriver National Institute of Child Health and Human Development; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
- Language
- English
- Date published
- 04/01/2020
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology; Biochemistry and Molecular Biology; Neonatology
- Record Identifier
- 9984293089002771
Metrics
15 Record Views