Journal article
Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive and Language Performance in Children Born Extremely Preterm
The Journal of pediatrics, Vol.204, pp.148-156.e4
01/2019
DOI: 10.1016/j.jpeds.2018.08.059
PMCID: PMC6394414
PMID: 30292492
Abstract
To investigate associations in toddlers born extremely preterm (<28 weeks) between neonatal neuroimaging and 18- to 22-month developmental and behavioral outcomes.
Cohort analysis from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network Surfactant Positive Airway Pressure and Pulse Oximetry Trial Neuroimaging and Neurodevelopmental Outcomes Study of infants born extremely preterm. Subjects underwent cranial ultrasonography and near-term magnetic resonance imaging (MRI). At 18-22 months of corrected age, the assessment included the Brief Infant Toddler Social Emotional Assessment (BITSEA) Problem and Competence Scale scores and the Bayley Scales of Infant Development, Third Edition (Bayley-III). The BITSEA Problem Scale assesses dysregulation; the Competence Scale assesses social-emotional competence. We examined associations of Problem and Competence scores and positive screen rates with cranial ultrasonography and near-term MRI. Mean BITSEA and Bayley-III scores were compared using ANOVA and positive screen rates with the χ2 test. We computed correlations between BITSEA and Bayley-III scores.
Of the 397 children, positive BITSEA screens were found in 34% for the Problem score and 26% for the Competence score. Presence of lesions on near-term MRI that included cerebellar lesions were significantly associated with lower BITSEA Competence but not with Problem scores; Competence scores were inversely related to the presence/significance of lesions. Positive screens on Competence scores and on both Competence and Problem scores were significantly associated with Bayley-III cognitive and language scores <85 (P < .001).
Social–emotional competence contributes to deficits in cognitive and language development. Presence of injury on near-term MRI that includes cerebellar lesions is associated with later social–emotional competence and may be a useful predictor to guide early assessment and intervention.
ClinicalTrials.gov: NCT00063063 and NCT00233324.
Details
- Title: Subtitle
- Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive and Language Performance in Children Born Extremely Preterm
- Creators
- Andrea F. Duncan - The University of Texas Health Science Center at HoustonCarla M. Bann - RTI InternationalAllison Dempsey - The University of Texas Health Science Center at HoustonMyriam Peralta-Carcelen - University of Alabama at BirminghamSusan Hintz - Stanford UniversityAlan H. Jobe - University of CincinnatiMichael S. Caplan - University of ChicagoAbbot R. Laptook - Brown UniversityBetty R. Vohr - Brown UniversityWilliam Oh - Brown UniversityAngelita M. Hensman - Brown UniversityBarbara Alksninis - Brown UniversityDawn Andrews - Brown UniversityKristen Angela - Brown UniversitySusan Barnett - Brown UniversityBill Cashore - Brown UniversityMelinda Caskey - Brown UniversityKim Francis - Brown UniversityDan Gingras - Brown UniversityKatharine Johnson - Brown UniversityTheresa M. Leach - Brown UniversityBonnie E. Stephens - Brown UniversityVictoria E. Watson - Brown UniversityMichele C. Walsh - Case Western Reserve UniversityAvroy A. Fanaroff - Case Western Reserve UniversityNancy S. Newman - Case Western Reserve UniversityDeanne E. Wilson-Costello - Case Western Reserve UniversityBonnie S. Siner - Case Western Reserve UniversityArlene Zadell - Case Western Reserve UniversityJulie DiFiore - Case Western Reserve UniversityMonika Bhola - Case Western Reserve UniversityHarriet G. Friedman - Case Western Reserve UniversityGulgun Yalcinkaya - Case Western Reserve UniversityDorothy Bulas - Children's National Medical Center, Washington, DCRonald N. Goldberg - Duke University School of MedicineC. Michael Cotten - Duke University School of MedicineRicki F. Goldstein - Duke University School of MedicinePatricia Ashley - Duke University School of MedicineKathy J. Auten - Duke University School of MedicineKimberley A. Fisher - Duke University School of MedicineKatherine A. Foy - Duke University School of MedicineSharon F. Freedman - Duke University School of MedicineKathryn E. Gustafson - Duke University School of MedicineMelody B. Lohmeyer - Duke University School of MedicineWilliam F. Malcolm - Duke University School of MedicineDavid K. Wallace - Duke University School of MedicineDavid P. Carlton - Emory UniversityBarbara J. Stoll - Emory UniversityIra Adams-Chapman - Emory UniversitySusie Buchter - Emory UniversityAnthony J. Piazza - Emory UniversitySheena Carter - Emory UniversitySobha Fritz - Emory UniversityEllen C. Hale - Emory UniversityAmy K. Hutchinson - Emory UniversityMaureen Mulligan LaRossa - Emory UniversityRosemary D. Higgins - Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentStephanie Wilson Archer - Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentGregory M. Sokol - Indiana UniversityBrenda B. Poindexter - Indiana UniversityAnna M. Dusick - Indiana UniversityJames A. Lemons - Indiana UniversityLeslie D. Wilson - Indiana UniversityFaithe Hamer - Indiana UniversityAnn B. Cook - Indiana UniversityDianne E. Herron - Indiana UniversityCarolyn Lytle - Indiana UniversityHeike M. Minnich - Indiana UniversityMary Anne Berberich - National Heart Lung and Blood InstituteCarol J. Blaisdell - National Heart Lung and Blood InstituteDorothy B. Gail - National Heart Lung and Blood InstituteJames P. Kiley - National Heart Lung and Blood InstituteAbhik Das - RTI InternationalMarie G. Gantz - RTI InternationalJamie E. Newman - RTI InternationalHelen Cheng - RTI InternationalBetty K. Hastings - RTI InternationalElizabeth M. McClure - RTI InternationalJeanette O'Donnell Auman - RTI InternationalCarolyn Petrie Huitema - RTI InternationalW. Kenneth Poole - RTI InternationalJames W. Pickett - RTI InternationalDennis Wallace - RTI InternationalLisa A. Wrage - RTI InternationalKristin M. Zaterka-Baxter - RTI InternationalKrisa P. Van Meurs - Stanford UniversityDavid K. Stevenson - Stanford UniversityM. Bethany Ball - Stanford UniversityPatrick D. Barnes - Stanford UniversityBarbara Bentley - Stanford UniversityElizabeth F. Bruno - Stanford UniversityMaria Elena DeAnda - Stanford UniversityAnne M. DeBattista - Stanford UniversityJean G. Kohn - Stanford UniversityMelinda S. Proud - Stanford UniversityRenee P. Pyle - Stanford UniversityHali E. Weiss - Stanford UniversityIvan D. Frantz - Tufts Medical CenterJohn M. Fiascone - Tufts Medical CenterElisabeth C. McGowan - Tufts Medical CenterAnne Furey - Tufts Medical CenterBrenda L. MacKinnon - Tufts Medical CenterEllen Nylen - Tufts Medical CenterAna Brussa - Tufts Medical CenterCecelia Sibley - Tufts Medical CenterWaldemar A. Carlo - University of Alabama at BirminghamNamasivayam Ambalavanan - University of Alabama at BirminghamMonica V. Collins - University of Alabama at BirminghamShirley S. Cosby - University of Alabama at BirminghamVivien A. Phillips - University of Alabama at BirminghamKirstin J. Bailey - University of Alabama at BirminghamFred J. Biasini - University of Alabama at BirminghamMaria Hopkins - University of Alabama at BirminghamKristen C. Johnston - University of Alabama at BirminghamKathleen G. Nelson - University of Alabama at BirminghamCryshelle S. Patterson - University of Alabama at BirminghamRichard V. Rector - University of Alabama at BirminghamLeslie Rodriguez - University of Alabama at BirminghamAmanda Soong - University of Alabama at BirminghamSally Whitley - University of Alabama at BirminghamSheree York - University of Alabama at BirminghamNeil N. Finer - University of California San Diego Medical CenterMaynard R. Rasmussen - University of California San Diego Medical CenterPaul R. Wozniak - University of California San Diego Medical CenterYvonne E. Vaucher - University of California San Diego Medical CenterWade Rich - University of California San Diego Medical CenterKathy Arnell - University of California San Diego Medical CenterRene Barbieri-Welge - University of California San Diego Medical CenterAyala Ben-Tall - University of California San Diego Medical CenterRenee Bridge - University of California San Diego Medical CenterClarence Demetrio - University of California San Diego Medical CenterMartha G. Fuller - University of California San Diego Medical CenterElaine Ito - University of California San Diego Medical CenterMeghan Lukasik - University of California San Diego Medical CenterDeborah Pontillo - University of California San Diego Medical CenterDonna Posin - University of California San Diego Medical CenterCheryl Runyan - University of California San Diego Medical CenterJames Wilkes - University of California San Diego Medical CenterPaul Zlotnik - University of California San Diego Medical CenterEdward F. Bell - University of IowaJohn A. Widness - University of IowaMichael J. Acarregui - University of Iowa Children's Hospital, Iowa City, IAJonathan M. Klein - University of IowaTarah T. Colaizy - University of IowaKaren J. Johnson - University of IowaDiane L. Eastman - University of Iowa Children's Hospital, Iowa City, IAShahnaz Duara - University of MiamiCharles R. Bauer - University of MiamiRuth Everett-Thomas - University of MiamiMaria Calejo - University of MiamiAlexis N. Diaz - University of MiamiSilvia M. Frade Eguaras - University of MiamiAndrea Garcia - University of MiamiKasey Hamlin-Smith - University of MiamiMichelle Harwood Berkowits - University of MiamiSylvia Hiriart-Fajardo - University of MiamiElaine O. Mathews - University of MiamiHelina Pierre - University of MiamiArielle Riguard - University of MiamiAlexandra Stroerger - University of MiamiKristi L. Watterberg - University of New MexicoRobin K. Ohls - University of New MexicoJanell Fuller - University of New Mexico Health Sciences Center, Albuqurque, NMJulie Rohr - University of New Mexico Health Sciences Center, Albuqurque, NMConra Backstrom Lacy - University of New MexicoJean Lowe - University of New MexicoRebecca Montman - University of New Mexico Health Sciences Center, Albuqurque, NMSandra Brown - University of New Mexico Health Sciences Center, Albuqurque, NMNirupama Laroia - University of Rochester Medical CenterDale L. Phelps - University of Rochester Medical CenterGary J. Myers - University of Rochester Medical CenterGary D. Markowitz - University of Rochester Medical CenterLinda J. Reubens - University of Rochester Medical CenterDiane Hust - University of Rochester Medical CenterLisa Augostino - University of Rochester Medical CenterJulie Babish Johnson - University of Rochester Medical CenterErica Burnell - University of Rochester Medical CenterHarris Gelbard - University of Rochester Medical CenterRosemary L. Jensen - University of Rochester Medical CenterEmily Kushner - University of Rochester Medical CenterJoan Merzbach - University of Rochester Medical CenterJonathan Mink - University of Rochester Medical CenterCarlos Torres - University of Rochester Medical CenterDavid Wang - University of Rochester Medical CenterKelley Yost - University of Rochester Medical CenterPablo J. Sánchez - The University of Texas Southwestern Medical CenterCharles R. Rosenfeld - The University of Texas Southwestern Medical CenterWalid A. Salhab - The University of Texas Southwestern Medical CenterRoy J. Heyne - The University of Texas Southwestern Medical CenterSally S. Adams - The University of Texas Southwestern Medical CenterJames Allen - The University of Texas Southwestern Medical CenterLaura Grau - The University of Texas Southwestern Medical CenterAlicia Guzman - The University of Texas Southwestern Medical CenterGaynelle Hensley - The University of Texas Southwestern Medical CenterElizabeth T. Heyne - The University of Texas Southwestern Medical CenterJackie F. Hickman - The University of Texas Southwestern Medical CenterMelissa H. Leps - The University of Texas Southwestern Medical CenterLinda A. Madden - The University of Texas Southwestern Medical CenterMelissa Martin - The University of Texas Southwestern Medical CenterNancy A. Miller - The University of Texas Southwestern Medical CenterJanet S. Morgan - The University of Texas Southwestern Medical CenterAraceli Solis - The University of Texas Southwestern Medical CenterLizette E. Torres - The University of Texas Southwestern Medical CenterCatherine Twell Boatman - The University of Texas Southwestern Medical CenterDiana M. Vasil - The University of Texas Southwestern Medical CenterKathleen A. Kennedy - The University of Texas Health Science Center at HoustonJon E. Tyson - The University of Texas Health Science Center at HoustonPatricia W. Evans - The University of Texas Health Science Center at HoustonEsther G. Akpa - The University of Texas Health Science Center at HoustonNora I. Alaniz - The University of Texas Health Science Center at HoustonBeverly Foley Harris - The University of Texas Health Science Center at HoustonCharles Green - The University of Texas Health Science Center at HoustonMargarita Jiminez - The University of Texas Health Science Center at HoustonAnna E. Lis - The University of Texas Health Science Center at HoustonSarah Martin - The University of Texas Health Science Center at HoustonGeorgia E. McDavid - The University of Texas Health Science Center at HoustonBrenda H. Morris - The University of Texas Health Science Center at HoustonMargaret L. Poundstone - The University of Texas Health Science Center at HoustonStacy Reddoch - The University of Texas Health Science Center at HoustonSaba Siddiki - The University of Texas Health Science Center at HoustonPatti L. Pierce Tate - The University of Texas Health Science Center at HoustonSharon L. Wright - The University of Texas Health Science Center at HoustonBradley A. Yoder - University of UtahRoger G. Faix - University of UtahShawna Baker - University of UtahKarie Bird - University of UtahAnna E. Bullwinkle - University of UtahJill Burnett - University of UtahLaura Cole - University of UtahKaren A. Osborne - University of UtahCynthia Spencer - University of UtahR. Edison Steele - University of UtahMichael Steffen - University of UtahKimberlee Weaver-Lewis - University of UtahT. Michael O'Shea - Atrium Health Wake Forest BaptistRobert G. Dillard - Atrium Health Wake Forest BaptistLisa K. Washburn - Atrium Health Wake Forest BaptistNancy J. Peters - Atrium Health Wake Forest BaptistBarbara G. Jackson - Atrium Health Wake Forest BaptistKorinne Chiu - Atrium Health Wake Forest BaptistDeborah Evans Allred - Atrium Health Wake Forest BaptistDonald J. Goldstein - Atrium Health Wake Forest BaptistRaquel Halfond - Atrium Health Wake Forest BaptistCarroll Peterson - Atrium Health Wake Forest BaptistEllen L. Waldrep - Atrium Health Wake Forest BaptistCherrie D. Welch - Atrium Health Wake Forest BaptistMelissa Whalen Morris - Atrium Health Wake Forest BaptistGail Wiley Hounshell - Atrium Health Wake Forest BaptistSeetha Shankaran - Wayne State UniversityBeena G. Sood - Wayne State UniversityThomas L. Slovis - Wayne State UniversityAthina Pappas - Wayne State UniversityRebecca Bara - Wayne State UniversityElizabeth Billian - Wayne State UniversityLaura A. Goldston - Wayne State UniversityMary Johnson - Wayne State UniversityNational Institute of Child Health and Development Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.204, pp.148-156.e4
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.jpeds.2018.08.059
- PMID
- 30292492
- PMCID
- PMC6394414
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Grant note
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (http://dx.doi.org/10.13039/100009633) National Institutes of Health (http://dx.doi.org/10.13039/100000002)
- Language
- English
- Date published
- 01/2019
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984353943002771
Metrics
15 Record Views