Journal article
Behavioral cross-sensitization between DOCA-induced sodium appetite and cocaine-induced locomotor behavior
Pharmacology, biochemistry and behavior, Vol.98(3), pp.440-448
05/2011
DOI: 10.1016/j.pbb.2011.02.016
PMCID: PMC3086042
PMID: 21352848
Abstract
Behavioral sensitization involves increases in the magnitude of a response to a stimulus after repeated exposures to the same response initiator. Administration of psychomotor stimulants and the induction of appetitive motivational states associated with natural reinforcers like sugar and salt are among experimental manipulations producing behavioral sensitization. In rats, repeated administration of the mineralocorticoid agonist deoxycorticosterone acetate (DOCA) initially induces incremental increases in daily hypertonic saline consumption (i.e., sensitization of sodium appetite) in spite of the retention of sodium. The present studies investigated whether sodium appetite sensitization induced by DOCA shares mechanisms similar to those of psychomotor stimulant-induced sensitization, and whether there is evidence for reciprocal cross-sensitization. In Experiments 1 and 3, rats received control or cocaine treatments to induce locomotor sensitization. A week later DOCA (or vehicle) was administered to generate a sodium appetite. Animals pretreated with cocaine showed a greater sodium appetite. In Experiment 2, the order of the putative sensitizing treatments was reversed. Rats first received either a series of DOCA or vehicle treatments either with or without access to saline and were later tested for sensitization of the locomotor response to cocaine. Animals pretreated with DOCA without access to saline showed greater locomotor responses to cocaine than animals receiving vehicle treatments. Together these experiments indicate that treatments generating a sustained salt appetite and producing cocaine-induced psychomotor responses show reciprocal behavioral cross-sensitization. The underlying mechanisms accounting for this relationship may be the fact that psychostimulants and an unresolved craving for sodium can act as potent stressors.
Details
- Title: Subtitle
- Behavioral cross-sensitization between DOCA-induced sodium appetite and cocaine-induced locomotor behavior
- Creators
- Martin J Acerbo - Departments of Psychology, Pharmacology, and Health and Human Physiology, and the Cardiovascular Center, The University of Iowa, Iowa City, IA 52242, USAAlan Kim Johnson
- Resource Type
- Journal article
- Publication Details
- Pharmacology, biochemistry and behavior, Vol.98(3), pp.440-448
- DOI
- 10.1016/j.pbb.2011.02.016
- PMID
- 21352848
- PMCID
- PMC3086042
- NLM abbreviation
- Pharmacol Biochem Behav
- ISSN
- 0091-3057
- eISSN
- 1873-5177
- Publisher
- United States
- Grant note
- R01 DK066086 / NIDDK NIH HHS HL 098207 / NHLBI NIH HHS R01 HL098207-01A1 / NHLBI NIH HHS R01 HL098207 / NHLBI NIH HHS R01 DK066086-05 / NIDDK NIH HHS HL 14388 / NHLBI NIH HHS P01 HL014388-37 / NHLBI NIH HHS MH 80241 / NIMH NIH HHS R01 HL057472-09 / NHLBI NIH HHS R01 MH080241 / NIMH NIH HHS P01 HL014388-39 / NHLBI NIH HHS T32 HL007121 / NHLBI NIH HHS P01 HL014388 / NHLBI NIH HHS R01 MH080241-02 / NIMH NIH HHS DK 66086 / NIDDK NIH HHS R01 HL057472 / NHLBI NIH HHS
- Language
- English
- Date published
- 05/2011
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
- Record Identifier
- 9984002449302771
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