Journal article
Behavioral disturbances in estrogen-related receptor alpha-null mice
Cell reports (Cambridge), Vol.11(3), pp.344-350
04/21/2015
DOI: 10.1016/j.celrep.2015.03.032
PMCID: PMC4440329
PMID: 25865889
Abstract
Eating disorders, such as anorexia nervosa and bulimia nervosa, are common and severe mental illnesses of unknown etiology. Recently, we identified a rare missense mutation in the transcription factor estrogen-related receptor alpha (ESRRA) that is associated with the development of eating disorders. However, little is known about ESRRA function in the brain. Here, we report that Esrra is expressed in the mouse brain and demonstrate that Esrra levels are regulated by energy reserves. Esrra-null female mice display a reduced operant response to a high-fat diet, compulsivity/behavioral rigidity, and social deficits. Selective Esrra knockdown in the prefrontal and orbitofrontal cortices of adult female mice recapitulates reduced operant response and increased compulsivity, respectively. These results indicate that Esrra deficiency in the mouse brain impairs behavioral responses in multiple functional domains.
Details
- Title: Subtitle
- Behavioral disturbances in estrogen-related receptor alpha-null mice
- Creators
- Huxing Cui - Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USAYuan Lu - Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USAMichael Z Khan - Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USARachel M Anderson - Department of Psychology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USALatisha McDaniel - Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USAHannah E Wilson - Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USATerry C Yin - Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USAJason J Radley - Department of Psychology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA; Interdisciplinary Neuroscience Program, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USAAndrew A Pieper - Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA; Department of Neurology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA; Interdisciplinary Neuroscience Program, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USAMichael Lutter - Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA; Interdisciplinary Neuroscience Program, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA. Electronic address: michael-lutter@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Cell reports (Cambridge), Vol.11(3), pp.344-350
- Publisher
- United States
- DOI
- 10.1016/j.celrep.2015.03.032
- PMID
- 25865889
- PMCID
- PMC4440329
- ISSN
- 2211-1247
- eISSN
- 2211-1247
- Grant note
- P30 ES005605 / NIEHS NIH HHS MH-095972 / NIMH NIH HHS R01 MH095972 / NIMH NIH HHS
- Language
- English
- Date published
- 04/21/2015
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology
- Record Identifier
- 9984040318902771
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