Journal article
Behavioral effects of congenital ventromedial prefrontal cortex malformation
BMC neurology, Vol.11(1), pp.151-151
12/02/2011
DOI: 10.1186/1471-2377-11-151
PMCID: PMC3265436
PMID: 22136635
Abstract
Background: A detailed behavioral profile associated with focal congenital malformation of the ventromedial prefrontal cortex (vmPFC) has not been reported previously. Here we describe a 14 year-old boy, B.W., with neurological and psychiatric sequelae stemming from focal cortical malformation of the left vmPFC.
Case presentation: B.W.'s behavior has been characterized through extensive review Patience of clinical and personal records along with behavioral and neuropsychological testing. A central feature of the behavioral profile is severe antisocial behavior. He is aggressive, manipulative, and callous; features consistent with psychopathy. Other problems include: egocentricity, impulsivity, hyperactivity, lack of empathy, lack of respect for authority, impaired moral judgment, an inability to plan ahead, and poor frustration tolerance.
Conclusions: The vmPFC has a profound contribution to the development of human prosocial behavior. B.W. demonstrates how a congenital lesion to this cortical region severely disrupts this process.
Details
- Title: Subtitle
- Behavioral effects of congenital ventromedial prefrontal cortex malformation
- Creators
- Aaron D Boes - Department of Neurology, University of Iowa. 200 Hawkins Drive, 2007 RCP, Iowa City, IA 52242. USAAmanda Hornaday Grafft - Department of Neurology, University of Iowa. 200 Hawkins Drive, 2007 RCP, Iowa City, IA 52242. USACharuta Joshi - Department of Neurology, University of Iowa. 200 Hawkins Drive, 2007 RCP, Iowa City, IA 52242. USANathaniel A Chuang - Department of Neurology, University of Iowa. 200 Hawkins Drive, 2007 RCP, Iowa City, IA 52242. USAPeg Nopoulos - Department of Neurology, University of Iowa. 200 Hawkins Drive, 2007 RCP, Iowa City, IA 52242. USASteven W Anderson - Department of Neurology, University of Iowa. 200 Hawkins Drive, 2007 RCP, Iowa City, IA 52242. USA
- Resource Type
- Journal article
- Publication Details
- BMC neurology, Vol.11(1), pp.151-151
- DOI
- 10.1186/1471-2377-11-151
- PMID
- 22136635
- PMCID
- PMC3265436
- NLM abbreviation
- BMC Neurol
- ISSN
- 1471-2377
- eISSN
- 1471-2377
- Publisher
- BioMed Central
- Language
- English
- Date published
- 12/02/2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984003981602771
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