Beneficial and Detrimental Roles of NLRs in Carcinogenesis

Ann M Janowski; Ryan Kolb; Weizhou Zhang; Fayyaz S Sutterwala

doi:10.3389/fimmu.2013.00370

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Beneficial and Detrimental Roles of NLRs in Carcinogenesis

Journal article

Open access

Peer reviewed

Beneficial and Detrimental Roles of NLRs in Carcinogenesis

Ann M Janowski, Ryan Kolb, Weizhou Zhang and Fayyaz S Sutterwala

Frontiers in immunology, Vol.4, pp.370-370

2013

DOI: 10.3389/fimmu.2013.00370

PMCID: PMC3824244

PMID: 24273542

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Abstract

Inflammation plays a critical role in tumorigenesis and can contribute to oncogenic mutations, tumor promotion, and angiogenesis. Tumor-promoting inflammation is driven by many factors including the presence of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18. One major source of IL-1β and IL-18 secretion is through the activation of inflammasomes. Inflammasomes are multi-protein complexes that upon activation lead to the processing and secretion of IL-1β and IL-18 mediated by the cysteine protease caspase-1. Several inflammasomes, including NLRP3, NLRC4, and NLRP6, have been implicated in tumorigenesis. However, inflammasomes play divergent roles in different types of cancer reflecting the complexity of inflammation during tumorigenesis. Understanding the role of inflammasome activation during specific stages of tumorigenesis and also during cancer immunotherapy will help identify novel therapeutic targets that could improve treatment strategies for cancer patients. Here we will discuss recent advances in understanding the mechanism by which NLRs regulate carcinogenesis.

cancer

Immunology

interleukin-1

inflammasomes

NLR

interleukin-18

Details

Title: Subtitle: Beneficial and Detrimental Roles of NLRs in Carcinogenesis
Creators: Ann M Janowski - Inflammation Program, University of Iowa Carver College of Medicine
Ryan Kolb - Department of Pathology, University of Iowa Carver College of Medicine
Weizhou Zhang - Department of Pathology, University of Iowa Carver College of Medicine
Fayyaz S Sutterwala - Inflammation Program, University of Iowa Carver College of Medicine
Resource Type: Journal article
Publication Details: Frontiers in immunology, Vol.4, pp.370-370
DOI: 10.3389/fimmu.2013.00370
PMID: 24273542
PMCID: PMC3824244
NLM abbreviation: Front Immunol
ISSN: 1664-3224
eISSN: 1664-3224
Publisher: Frontiers Media S.A
Language: English
Date published: 2013
Academic Unit: Microbiology and Immunology; Radiation Oncology
Record Identifier: 9984083284702771

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