Benzophenone and Fimetarone Derivatives from the Coprophilous Fungus Delitschia confertaspora

Dinith R Jayanetti; Yan Li; Geoffrey A Bartholomeusz; Gerald F Bills; James B Gloer

doi:10.1021/acs.jnatprod.6b01091

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Benzophenone and Fimetarone Derivatives from the Coprophilous Fungus Delitschia confertaspora

Journal article

Peer reviewed

Benzophenone and Fimetarone Derivatives from the Coprophilous Fungus Delitschia confertaspora

Dinith R Jayanetti, Yan Li, Geoffrey A Bartholomeusz, Gerald F Bills and James B Gloer

Journal of natural products (Washington, D.C.), Vol.80(3), pp.707-712

03/24/2017

DOI: 10.1021/acs.jnatprod.6b01091

PMID: 28128947

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Abstract

Studies of the genome-sequenced, flutimide-producing coprophilous fungus Delitschia confertaspora (ATCC 74209), originally obtained from a sample of rock hyrax (Procavia capensis) dung collected in Namibia, led to the discovery of three new highly aromatic natural products named delicoferones A-B (1-2) and fimetarone B (3). The new benzophenone derivatives 1 and 2 have a somewhat unusual skeleton that incorporates three aromatic rings linked via two ketone carbonyl groups, while 3 contains a spiro[chroman-3,7'-isochromene]-4,6'(8'H) skeleton reported only once previously. The structures of these compounds were assigned mainly by analysis of 2D NMR and HRESITOFMS data.

Benzophenones - chemistry

Animals

Namibia

Nuclear Magnetic Resonance, Biomolecular

Hyraxes

Molecular Structure

Fungi - chemistry

Spiro Compounds - chemistry

Spiro Compounds - isolation & purification

Benzophenones - isolation & purification

Details

Title: Subtitle: Benzophenone and Fimetarone Derivatives from the Coprophilous Fungus Delitschia confertaspora
Creators: Dinith R Jayanetti - Department of Chemistry, University of Iowa , Iowa City, Iowa 52242, United States
Yan Li - Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston , 1881 East Road, Houston, Texas 77054, United States
Geoffrey A Bartholomeusz - Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center , Houston, Texas 77054, United States
Gerald F Bills - Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston , 1881 East Road, Houston, Texas 77054, United States
James B Gloer - Department of Chemistry, University of Iowa , Iowa City, Iowa 52242, United States
Resource Type: Journal article
Publication Details: Journal of natural products (Washington, D.C.), Vol.80(3), pp.707-712
Publisher: United States
DOI: 10.1021/acs.jnatprod.6b01091
PMID: 28128947
ISSN: 0163-3864
eISSN: 1520-6025
Grant note: S10 RR025500 / NCRR NIH HHS
Language: English
Date published: 03/24/2017
Academic Unit: Chemistry
Record Identifier: 9983985996102771

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