Journal article
Best practice recommendations for the use of hepatitis C viremic donor organs for hepatitis C virus naïve recipients
Clinical transplantation, Vol.35(8), pp.e14381-n/a
08/2021
DOI: 10.1111/ctr.14381
PMID: 34086371
Abstract
The combination of the transplant organ deficit, the increase in HCV nucleic acid positive donors (HCV NAT+), and the development of direct-acting antiviral agents (DAAs) has resulted in a rapid increase in HCV NAT+ organ transplants into HCV naïve recipients. Early clinical experience with HCV NAT+ donor organs has shown promising outcomes; however, best practices are lacking to guide transplant programs during all phases of patient care. Transplant programs developing protocols for the utilization of HCV NAT+ organs will need a multidisciplinary team to address all aspects of pre-transplant and post-transplant patient care. Reports of fibrosing cholestatic hepatitis in HCV NAT+ organ transplant recipients receiving delayed DAA initiation highlight the need for the transplant community to develop safe and effective protocols. A failure to do so will inevitably lead to the erosion of public trust from cases of missed or inadequately treated donor-derived HCV infections. Herein, we provide best practice guidelines for the utilization of HCV NAT+ organs into HCV-negative recipients based on literature review and expert opinion from the faculty of the ASTS Standards and Quality Committee.
Details
- Title: Subtitle
- Best practice recommendations for the use of hepatitis C viremic donor organs for hepatitis C virus naïve recipients
- Creators
- Zoe A. Stewart - New York UniversityShimul A. Shah - University of CincinnatiJason A. Rolls - Christiana Care Health SystemJames V. Guarrera - Rutgers, The State University of New JerseyRaja Kandaswamy - University of MinnesotaDavid A. Axelrod - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Clinical transplantation, Vol.35(8), pp.e14381-n/a
- DOI
- 10.1111/ctr.14381
- PMID
- 34086371
- ISSN
- 0902-0063
- eISSN
- 1399-0012
- Language
- English
- Date published
- 08/2021
- Academic Unit
- Surgery
- Record Identifier
- 9984322944102771
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