Beta modulation reflects name retrieval in the human anterior temporal lobe: an intracranial recording study

Taylor J Abel; Ariane E Rhone; Kirill V Nourski; Timothy K Ando; Hiroyuki Oya; Christopher K Kovach; Hiroto Kawasaki; Matthew A Howard III; Daniel Tranel

doi:10.1152/jn.00012.2016

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Beta modulation reflects name retrieval in the human anterior temporal lobe: an intracranial recording study

Journal article

Open access

Peer reviewed

Beta modulation reflects name retrieval in the human anterior temporal lobe: an intracranial recording study

Taylor J Abel, Ariane E Rhone, Kirill V Nourski, Timothy K Ando, Hiroyuki Oya, Christopher K Kovach, Hiroto Kawasaki, Matthew A Howard III and Daniel Tranel

Journal of neurophysiology, Vol.115(6), pp.3052-3061

06/01/2016

DOI: 10.1152/jn.00012.2016

PMCID: PMC4946599

PMID: 27075536

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https://doi.org/10.1152/jn.00012.2016View

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Abstract

Naming people, places, and things is a fundamental human ability that is often impaired in patients with language-dominant anterior temporal lobe (ATL) dysfunction or ATL resection as part of epilepsy treatment. Convergent lines of evidence point to the importance of the ATL in name retrieval. The physiologic mechanisms that mediate name retrieval in the ATL, however, are not well understood. The purpose of this study was to characterize the electrophysiologic responses of the human ATL during overt cued naming of famous people and objects. Eight neurosurgical patients with suspected temporal lobe epilepsy who underwent implantation of intracranial electrodes for seizure focus localization were the subjects of this study. Specialized coverage of the ATL was achieved in each subject. The subjects named pictures of U.S. presidents and images of common hand-held tools. Event-related band power was measured for each ATL recording site. Both the left and right ATL demonstrated robust and focal increases in beta-band (14-30 Hz) power during person and tool naming. The onset of this response typically occurred at 400 ms but sometimes as early as 200 ms. Visual naming of famous people and tools is associated with robust and localized modulation of the beta band in both the left and right ATL. Measurement of visual naming responses may provide the groundwork for future mapping modalities to localize eloquent cortex in the ATL.

Electroencephalography

Cues

Humans

Middle Aged

Epilepsy, Temporal Lobe - physiopathology

Male

Electrodes, Implanted

Epilepsy, Temporal Lobe - surgery

Association Learning - physiology

Names

Neuropsychological Tests

Young Adult

Temporal Lobe - physiopathology

Fourier Analysis

Mental Recall - physiology

Beta Rhythm - physiology

Brain Mapping

Adult

Photic Stimulation

Details

Title: Subtitle: Beta modulation reflects name retrieval in the human anterior temporal lobe: an intracranial recording study
Creators: Taylor J Abel - Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa; and Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa taylor-abel@uiowa.edu
Ariane E Rhone - Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa; and
Kirill V Nourski - Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa; and
Timothy K Ando - Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa; and
Hiroyuki Oya - Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa; and
Christopher K Kovach - Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa; and
Hiroto Kawasaki - Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa; and
Matthew A Howard III - Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa; and
Daniel Tranel - Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Resource Type: Journal article
Publication Details: Journal of neurophysiology, Vol.115(6), pp.3052-3061
DOI: 10.1152/jn.00012.2016
PMID: 27075536
PMCID: PMC4946599
NLM abbreviation: J Neurophysiol
ISSN: 0022-3077
eISSN: 1522-1598
Publisher: United States
Grant note: T35 HL007485 / NHLBI NIH HHS R01 DC004290 / NIDCD NIH HHS F32 NS087664 / NINDS NIH HHS
Language: English
Date published: 06/01/2016
Academic Unit: Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984002486702771

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