Journal article
Beyond MITF: Multiple transcription factors directly regulate the cellular phenotype in melanocytes and melanoma
Pigment cell and melanoma research, Vol.30(5), pp.454-466
09/2017
DOI: 10.1111/pcmr.12611
PMCID: PMC5939569
PMID: 28649789
Abstract
MITF governs multiple steps in the development of melanocytes, including specification from neural crest, growth, survival, and terminal differentiation. In addition, the level of MITF activity determines the phenotype adopted by melanoma cells, whether invasive, proliferative, or differentiated. However, MITF does not act alone. Here, we review literature on the transcription factors that co-regulate MITF-dependent genes. ChIP-seq studies have indicated that the transcription factors SOX10, YY1, and TFAP2A co-occupy subsets of regulatory elements bound by MITF in melanocytes. Analyses at single loci also support roles for LEF1, RB1, IRF4, and PAX3 acting in combination with MITF, while sequence motif analyses suggest that additional transcription factors colocalize with MITF at many melanocyte-specific regulatory elements. However, the precise biochemical functions of each of these MITF collaborators and their contributions to gene expression remain to be elucidated. Analogous to the transcriptional networks in morphogen-patterned tissues during embryogenesis, we anticipate that the level of MITF activity is controlled not only by the concentration of activated MITF, but also by additional transcription factors that either quantitatively or qualitatively influence the expression of MITF-target genes.
Details
- Title: Subtitle
- Beyond MITF: Multiple transcription factors directly regulate the cellular phenotype in melanocytes and melanoma
- Creators
- Hannah E Seberg - Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA, USAEric Van Otterloo - SDM-Craniofacial Biology, University of Colorado - Anschutz Medical Campus, Aurora, CO, USARobert A Cornell - Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Pigment cell and melanoma research, Vol.30(5), pp.454-466
- DOI
- 10.1111/pcmr.12611
- PMID
- 28649789
- PMCID
- PMC5939569
- NLM abbreviation
- Pigment Cell Melanoma Res
- ISSN
- 1755-1471
- eISSN
- 1755-148X
- Publisher
- England
- Grant note
- R01 DE023575 / NIDCR NIH HHS K99 DE026823 / NIDCR NIH HHS R01 AR062547 / NIAMS NIH HHS P30 CA086862 / NCI NIH HHS
- Language
- English
- Date published
- 09/2017
- Academic Unit
- Anatomy and Cell Biology; Craniofacial Anomalies Research Center; Dental Research; Periodontics
- Record Identifier
- 9984025445102771
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