Journal article
Bilateral oophorectomy and colorectal cancer incidence and mortality in the Women's Health Initiative
Cancer epidemiology, biomarkers & prevention, Vol.32(11), pp.1668-1671
11/01/2023
DOI: 10.1158/1055-9965.EPI-23-0198
PMID: 37566400
Abstract
The few cohort studies examining oophorectomy and colorectal cancer risk provide mixed results. Therefore, we examined this issue in Women's Health Initiative (WHI) Observational Study (OS) participants.
A total of 71,312 postmenopausal women were followed for 22.1 years (median). At enrollment, 55,643 (78%) had intact ovaries and 15,669 (22%) had undergone a bilateral oophorectomy. Colorectal cancers were verified by central medical record review with mortality findings enhanced by National Death Index queries.
With 1,421 incident colorectal cancers, 450 colorectal cancer-specific mortalities, after controlling for covariates, bilateral oophorectomy was not associated with colorectal cancer incidence or colorectal cancer mortality.
No significant associations between oophorectomy and colorectal cancer incidence and mortality were seen in a large cohort study with long follow-up.
As the oophorectomy and colorectal cancer question remains open, further studies of high quality, even with null findings, should be encouraged.
Details
- Title: Subtitle
- Bilateral oophorectomy and colorectal cancer incidence and mortality in the Women's Health Initiative
- Creators
- Mihae Song - City Of Hope National Medical CenterRebecca A Nelson - City Of Hope National Medical CenterLaura Kruper - City Of Hope National Medical CenterJoanne Mortimer - City Of Hope National Medical CenterJuhua Luo - Indiana University BloomingtonSu Yon Jung - University of California, Los AngelesRobert B Wallace - University of IowaRowan Chlebowski - The Lundquist Institute
- Resource Type
- Journal article
- Publication Details
- Cancer epidemiology, biomarkers & prevention, Vol.32(11), pp.1668-1671
- DOI
- 10.1158/1055-9965.EPI-23-0198
- PMID
- 37566400
- NLM abbreviation
- Cancer Epidemiol Biomarkers Prev
- ISSN
- 1055-9965
- eISSN
- 1538-7755
- Grant note
- name: National Cancer Institute, award: R01 CA119171; name: National Cancer Institute, award: R01 CA10921; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: HHSN268201600018C; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: HHSN268201600001C
- Language
- English
- Electronic publication date
- 08/11/2023
- Date published
- 11/01/2023
- Academic Unit
- Epidemiology; Injury Prevention Research Center
- Record Identifier
- 9984455491502771
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