Journal article
Bilateral optic neuropathy after short-term treatment with intravenous amiodarone
Klinische Monatsblatter fur Augenheilkunde, Vol.229(4), pp.431-432
04/01/2012
DOI: 10.1055/s-0031-1299164
PMID: 22496021
Abstract
Background
Originally Amiodarone, a diiodated benzofuran derivative, was developed in the year 1960 to treat angina pectoris. Nowadays it is mainly used to maintain a sinus rhythm in patients with atrial fibrillation or ventricular tachycardia. While amiodarone-related optic neuropathy has become a well-recognized entity, its exact cause is still unclear. A possible explanation accuses the intracytoplasmatic lamellar and granular bodies, which develop in multiple parts of the eye as in the cornea [1], lens, retina, and the optic nerve. This process may lead to an optic disc edema and later to optic nerve atrophy [2] [3]. The first amiodarone-associated side effects concerning the optic disc were described in 1987 by Feiner et al. as well as by Gittinger et al. [4] [5]. Usually, the interval between initiation of orally administered amiodarone treatment and onset of visual loss is several months [6]. No critical dosage and no critical time interval have been defined so far.
Details
- Title: Subtitle
- Bilateral optic neuropathy after short-term treatment with intravenous amiodarone
- Creators
- P P Ciechanowski - University Hospital of ZurichM Töteberg-HarmsJ Stürmer - Kantonsspital WinterthurM Kunz - Klinik HirslandenK Landau - University Hospital of ZurichV Sturm - University Hospital of Zurich
- Resource Type
- Journal article
- Publication Details
- Klinische Monatsblatter fur Augenheilkunde, Vol.229(4), pp.431-432
- DOI
- 10.1055/s-0031-1299164
- PMID
- 22496021
- ISSN
- 0023-2165
- eISSN
- 1439-3999
- Language
- English
- Date published
- 04/01/2012
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984696576102771
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