Bilateral renal vein thrombosis secondary to membraneous glomerulonephritis: successful treatment with thrombolytic therapy

Natalie Weger; Stanislaw P Stawicki; Garrett Roll; Kevin M Hoddinott; John J Lukaszczyk

doi:10.1007/s10016-006-9029-8

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Bilateral renal vein thrombosis secondary to membraneous glomerulonephritis: successful treatment with thrombolytic therapy

Journal article

Peer reviewed

Bilateral renal vein thrombosis secondary to membraneous glomerulonephritis: successful treatment with thrombolytic therapy

Natalie Weger, Stanislaw P Stawicki, Garrett Roll, Kevin M Hoddinott and John J Lukaszczyk

Annals of vascular surgery, Vol.20(3), pp.411-414

05/2006

DOI: 10.1007/s10016-006-9029-8

PMID: 16604403

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Abstract

Renal vein thrombosis (RVT) is a rare phenomenon. Bilateral RVT is even less common. RVT has been reported as idiopathic or in association with puerperium, hypercoagulable states, membraneous glomerulonephritis (MGn), renal transplantation, malignancy, and renal vein instrumentation or trauma. Due to its rarity, the literature describing RVT consists mainly of isolated case reports and there are no consistent recommendations regarding diagnosis and treatment of this vascular emergency. We present a case of bilateral RVT associated with MGn. A 45-year-old man complaining of nonspecific abdominal pain of 2 days' duration was found to have bilateral RVT upon computed tomographic evaluation. He was successfully treated with emergent endovascular mechanical thrombectomy in conjunction with chemical thrombolysis and subsequently therapeutically anticoagulated. A renal biopsy demonstrated MGn, and the patient was placed on an appropriate medical regimen. He is well approximately 18 months later, with preserved renal function. Despite a multitude of potential causative mechanisms, all RVT patients should undergo a thorough workup for underlying hypercoagulable disorder and underlying benign or malignant renal causes. Treatment is aimed at prompt relief of venous obstruction and preservation of renal parenchymal function. Interventional radiological procedures, including thrombolysis and thrombectomy, have proven to be valuable in the treatment of RVT. Surgical options include thrombectomy and nephrectomy.

Glomerulonephritis, Membranous - surgery

Venous Thrombosis - drug therapy

Humans

Middle Aged

Venous Thrombosis - diagnostic imaging

Anticoagulants - therapeutic use

Male

Tomography, X-Ray Computed

Treatment Outcome

Phlebography

Thrombectomy

Renal Veins - diagnostic imaging

Glomerulonephritis, Membranous - drug therapy

Thrombolytic Therapy

Venous Thrombosis - surgery

Glomerulonephritis, Membranous - diagnostic imaging

Details

Title: Subtitle: Bilateral renal vein thrombosis secondary to membraneous glomerulonephritis: successful treatment with thrombolytic therapy
Creators: Natalie Weger - Department of Surgery, St. Luke's Hospital and Health Network, Bethlehem, PA 18015, USA
Stanislaw P Stawicki
Garrett Roll
Kevin M Hoddinott
John J Lukaszczyk
Resource Type: Journal article
Publication Details: Annals of vascular surgery, Vol.20(3), pp.411-414
Publisher: Netherlands
DOI: 10.1007/s10016-006-9029-8
PMID: 16604403
ISSN: 0890-5096
eISSN: 1615-5947
Language: English
Date published: 05/2006
Academic Unit: Surgery
Record Identifier: 9984051981702771

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