Journal article
Bile-pancreatic juice exclusion increases cholinergic M3 and CCK-A receptor expression and interleukin-6 production in ligation-induced acute pancreatitis
The American journal of surgery, Vol.188(5), pp.511-515
2004
DOI: 10.1016/j.amjsurg.2004.07.008
PMID: 15546560
Abstract
Using an original model, the Donor Rat Model, we showed that bile-pancreatic juice (BPJ) exclusion from gut exacerbates ligation-induced acute pancreatitis in rats. We also showed that muscarinic cholinergic M3 and CCK-A receptor expression is induced following duct ligation. Increased receptor number potentially could exacerbate cytokine production. We hypothesize that BPJ exclusion is responsible for M3 and CCK-A receptor induction and increased interleukin-6 (IL-6) production.
M3 and CCK-A receptor expression and IL-6 production were compared in rat pancreata 1 to 3 hours after duct ligation with or without BPJ replacement.
Our studies showed that BPJ replacement attenuates duct ligation–induced increases in M3 and CCK-A receptor expression and IL-6 production.
In this model, BPJ exclusion from gut induces M3 and CCK-A receptor expression and increases IL-6 production. In this experimental corollary of gallstone pancreatitis, BPJ exclusion from gut may play a key role in the mechanism of disease pathogenesis.
Details
- Title: Subtitle
- Bile-pancreatic juice exclusion increases cholinergic M3 and CCK-A receptor expression and interleukin-6 production in ligation-induced acute pancreatitis
- Creators
- Isaac Samuel - Department of Surgery, Veterans Affairs Medical Center & University of Iowa Roy J. and Lucille A. Carver College of Medicine, 200 Hawkins Dr., 4625 JCP, Iowa City, IA 52242, USAAsgar Zaheer - Department of Surgery, Veterans Affairs Medical Center & University of Iowa Roy J. and Lucille A. Carver College of Medicine, 200 Hawkins Dr., 4625 JCP, Iowa City, IA 52242, USASmita Zaheer - Department of Surgery, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USARory A Fisher - Department of Pharmacology, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- The American journal of surgery, Vol.188(5), pp.511-515
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.amjsurg.2004.07.008
- PMID
- 15546560
- ISSN
- 0002-9610
- eISSN
- 1879-1883
- Language
- English
- Date published
- 2004
- Academic Unit
- Neurology; Iowa Neuroscience Institute; Surgery; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040333802771
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