Journal article
Bioactive natural products from a sclerotium-colonizing isolate of Humicola fuscoatra
Journal of natural products (Washington, D.C.), Vol.65(11), pp.1734-1737
2002
DOI: 10.1021/np020295p
PMID: 12444718
Abstract
Chemical studies of an organic extract from solid-substrate fermentations of the mycoparasitic fungus Humicola fuscoatra NRRL 22980, originally isolated as a colonist of Aspergillus flavus sclerotia, afforded two new unrelated compounds that we have named fuscoatroside (1) and fuscoatramide (2). The structures of these metabolites were elucidated by analysis of NMR and MS data. Fuscoatroside (1) is a triterpenoid glycoside that exhibited activity in antifungal assays against A. flavus. This extract also contained the known metabolites 7-deoxysterigmatocystin, sterigmatocystin, isosclerone, and decarestrictines A1 and I.
Details
- Title: Subtitle
- Bioactive natural products from a sclerotium-colonizing isolate of Humicola fuscoatra
- Creators
- Biren K Joshi - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, United StatesJames B Gloer - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, United StatesDonald T Wicklow - Bioactive Agents Research Unit, Agricultural Research Service, National Center for Agricultural Utilization Research, United States Department of Agriculture, Peoria, Illinois 61604, United States
- Resource Type
- Journal article
- Publication Details
- Journal of natural products (Washington, D.C.), Vol.65(11), pp.1734-1737
- Publisher
- American Society of Pharmacognosy
- DOI
- 10.1021/np020295p
- PMID
- 12444718
- ISSN
- 0163-3864
- eISSN
- 1520-6025
- Language
- English
- Date published
- 2002
- Academic Unit
- Chemistry
- Record Identifier
- 9984216602202771
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