Journal article
Bioactive natural products from fungicolous Hawaiian isolates: secondary metabolites from a Phialemoniopsis sp
Mycology: Discovery, distribution and biosynthesis of fungal secondary metabolites, Vol.5(3), pp.120-129
07/03/2014
DOI: 10.1080/21501203.2014.931309
PMCID: PMC4205894
PMID: 25379336
Abstract
Chemical investigations of two fungal isolates initially identified as members of the genus Phialemonium are described. Both isolates were obtained as colonists of other fungi collected on the island of Hawaii and were later assigned as P. curvatum. However, P. curvatum has recently been reclassified as a member of a new genus (Phialemoniopsis) and renamed as Phialemoniopsis curvata. Studies of solid-substrate fermentation cultures of one of these isolates afforded an oxirapentyn analogue and destruxin A 4 as major components, while analysis of the second strain led to the isolation of several simple aromatic metabolites and a compound of mixed biogenetic origin called gabusectin that had previously been reported only in a patent. Structures were assigned mainly by detailed nuclear magnetic resonance and mass spectrometry analysis, and those of two of the major components were confirmed by X-ray crystallography. This report constitutes the first description of secondary metabolites from a member of the genus Phialemoniopsis.
Details
- Title: Subtitle
- Bioactive natural products from fungicolous Hawaiian isolates: secondary metabolites from a Phialemoniopsis sp
- Creators
- Amninder Kaur - Department of Chemistry, University of IowaKristina D Rogers - Department of Chemistry, University of IowaDale E Swenson - Department of Chemistry, University of IowaPatrick F Dowd - Bacterial Foodborne Pathogens & Mycology Research Unit, Agricultural Research Service, National Center for Agricultural Utilization Research, USDADonald T Wicklow - Bacterial Foodborne Pathogens & Mycology Research Unit, Agricultural Research Service, National Center for Agricultural Utilization Research, USDAJames B Gloer - Department of Chemistry, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Mycology: Discovery, distribution and biosynthesis of fungal secondary metabolites, Vol.5(3), pp.120-129
- Publisher
- Taylor & Francis
- DOI
- 10.1080/21501203.2014.931309
- PMID
- 25379336
- PMCID
- PMC4205894
- ISSN
- 2150-1203
- eISSN
- 2150-1211
- Language
- English
- Date published
- 07/03/2014
- Academic Unit
- Chemistry
- Record Identifier
- 9983985951202771
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