Bioavailability, efficacy, and tolerance of two sustained-release theophylline dosage forms in adult patients with bronchial asthma

J J Trautlein; L Demers; V Esler; E Field

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Bioavailability, efficacy, and tolerance of two sustained-release theophylline dosage forms in adult patients with bronchial asthma

Journal article

Peer reviewed

Bioavailability, efficacy, and tolerance of two sustained-release theophylline dosage forms in adult patients with bronchial asthma

J J Trautlein, L Demers, V Esler and E Field

Clinical therapeutics, Vol.4(4), pp.252-262

1981

PMID: 7332913

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Abstract

Twenty otherwise health adults with a diagnosis of reversible obstructive airways disease were treated for one month in a single-blind crossover study with approximately equivalent doses of Elixophyllin SR capsules or Theo-Dur tablets. Both products provided evidence of efficacy by improvement in pulmonary function tests, and both were well tolerated. There were no significant differences between the two products with regard to bioavailability, efficacy, or tolerance. Both dosage forms appeared to have similar kinetic properties within the context of the study.

Sleep Wake Disorders - chemically induced

Tablets

Humans

Middle Aged

Drug Tolerance

Biological Availability

Male

Asthma - drug therapy

Lung Volume Measurements

Theophylline - administration & dosage

Capsules

Asthma - blood

Adolescent

Adult

Female

Theophylline - adverse effects

Delayed-Action Preparations

Details

Title: Subtitle: Bioavailability, efficacy, and tolerance of two sustained-release theophylline dosage forms in adult patients with bronchial asthma
Creators: J J Trautlein
L Demers
V Esler
E Field
Resource Type: Journal article
Publication Details: Clinical therapeutics, Vol.4(4), pp.252-262
PMID: 7332913
ISSN: 0149-2918
eISSN: 1879-114X
Language: English
Date published: 1981
Academic Unit: Immunology; Internal Medicine
Record Identifier: 9984094704402771

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