Biobehavioral Factors and Cancer Progression: Physiological Pathways and Mechanisms

Susan K Lutgendorf; Anil K Sood

doi:10.1097/PSY.0b013e318235be76

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Biobehavioral Factors and Cancer Progression: Physiological Pathways and Mechanisms

Journal article

Open access

Peer reviewed

Biobehavioral Factors and Cancer Progression: Physiological Pathways and Mechanisms

Susan K Lutgendorf and Anil K Sood

Psychosomatic medicine, Vol.73(9), pp.724-730

2011

DOI: 10.1097/PSY.0b013e318235be76

PMCID: PMC3319047

PMID: 22021459

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https://www.ncbi.nlm.nih.gov/pmc/articles/3319047View

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Abstract

Epidemiological evidence increasingly has supported the role of biobehavioral risk factors such as social adversity, depression, and stress in cancer progression. This review describes in vitro, in vivo, and clinical studies demonstrating relationships between such processes and pathways involved in cancer progression. These include effects on the cellular immune response, angiogenesis, invasion, anoikis, and inflammation. Biobehavioral factors have been shown to contribute to the cross-talk between tumor and host cells in the tumor microenvironment and stress effects on host cells such as macrophages appear to be critical for many pathways involved in tumor progression. Some effects are bi-directional, in that tumor derived inflammation appears to affect central nervous system processes, giving rise to vegetative symptoms and contributing to dysregulation of the HPA axis with downstream effects on inflammatory control. Findings to date are reviewed and fruitful areas for future research are discussed.

social support

stress

anoikis

glucocorticoid

angiogenesis

Biobehavioral

beta-adrenergic

oncology

Details

Title: Subtitle: Biobehavioral Factors and Cancer Progression: Physiological Pathways and Mechanisms
Creators: Susan K Lutgendorf - Department of Psychology, Obstetrics and Gynecology, and Urology, University of Iowa
Anil K Sood - Departments of Gynecologic Oncology and Cancer Biology, UT MD Anderson Comprehensive Cancer Center
Resource Type: Journal article
Publication Details: Psychosomatic medicine, Vol.73(9), pp.724-730
DOI: 10.1097/PSY.0b013e318235be76
PMID: 22021459
PMCID: PMC3319047
NLM abbreviation: Psychosom Med
ISSN: 0033-3174
eISSN: 1534-7796
Grant note: R01 CA140933-03 || CA / National Cancer Institute : NCI
Language: English
Date published: 2011
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
Record Identifier: 9984065771402771

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