Journal article
Biobehavioral Pathways and Cancer Progression: Insights for Improving Well-Being and Cancer Outcomes
Integrative cancer therapies, Vol.21, pp.15347354221096081-15347354221096081
05/01/2022
DOI: 10.1177/15347354221096081
PMCID: PMC9118395
PMID: 35579197
Abstract
The relationship between psychosocial factors and cancer has intrigued people for centuries. In the last several decades there has been an expansion of mechanistic research that has revealed insights regarding how stress activates neuroendocrine stress-response systems to impact cancer progression. Here, we review emerging mechanistic findings on key pathways implicated in the effect of stress on cancer progression, including the cellular immune response, inflammation, angiogenesis, and metastasis, with a primary focus on the mediating role of the sympathetic nervous system. We discuss converging findings from preclinical and clinical cancer research that describe these pathways and research that reveals how these stress pathways may be targeted via pharmacological and mind-body based interventions. While further research is required, the body of work reviewed here highlights the need for and feasibility of an integrated approach to target stress pathways in cancer patients to achieve comprehensive cancer treatment.
Details
- Title: Subtitle
- Biobehavioral Pathways and Cancer Progression: Insights for Improving Well-Being and Cancer Outcomes
- Creators
- Aeson Chang - Monash UniversityErica K Sloan - Peter MacCallum Cancer CentreMichael H Antoni - University of MiamiJennifer M Knight - Medical College of WisconsinRachel Telles - Departments of Psychological and Brain Sciences, Obstetrics and Gynecology, and Urology, and Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USASusan K Lutgendorf - Departments of Psychological and Brain Sciences, Obstetrics and Gynecology, and Urology, and Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Integrative cancer therapies, Vol.21, pp.15347354221096081-15347354221096081
- DOI
- 10.1177/15347354221096081
- PMID
- 35579197
- PMCID
- PMC9118395
- NLM abbreviation
- Integr Cancer Ther
- ISSN
- 1534-7354
- eISSN
- 1552-695X
- Publisher
- SAGE Publishing
- Language
- English
- Date published
- 05/01/2022
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984258956702771
Metrics
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