Journal article
Biobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma
Brain, behavior, and immunity, Vol.50, pp.58-62
11/2015
DOI: 10.1016/j.bbi.2015.04.019
PMCID: PMC4631681
PMID: 25989110
Abstract
•Antioxidant enzyme activity was associated with tumor NE and mood in ovarian cancer.•MnSOD activity was positively related to depressed mood and tumor NE.•GPx1 activity was inversely related to fatigue and tumor NE.•GPx1 was positively associated with vigor.
Increased levels of reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide have been reported in many cancer cells and they have been implicated in carcinogenesis and tumor progression. Antioxidant enzymes, such as Manganese Superoxide Dismutase (MnSOD or SOD2) and Glutathione Peroxidase-1 (GPx1), act coordinately to neutralize ROS. These enzymes are also thought to contribute to cancer cell resistance to conventional radio-chemo-therapies. Although some relationships have been reported between psychosocial factors and the regulation of antioxidant enzymes, little is known about these relationships in the context of cancer progression.
The current study investigated the levels of MnSOD and GPx1in confirmed serous, high-grade tumor tissue from 60 ovarian cancer patients, and explored the relationship between the activity of these enzymes, the levels of tumor norepinephrine (NE), and patient mood as determined via pre-operative questionnaires. MnSOD activity was positively related to depressed mood (p=0.025) and tumor NE (p=0.023). In contrast, GPx1 activity was inversely related to fatigue (p=0.015) and tumor NE (p=0.009), and was positively associated with vigor (p=0.024). These findings suggest that psychological state and adrenergic signaling are linked with antioxidant enzyme activity in ovarian cancer and may have implications for patient treatments and outcomes.
Details
- Title: Subtitle
- Biobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma
- Creators
- Jennifer L Bayer - Department of Psychology, University of Iowa, United StatesDouglas R Spitz - Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, United StatesDesire Christensen - Carver College of Medicine, University of Iowa, United StatesMichael L McCormick - Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, United StatesDonna Farley - Department of Pharmacology, University of Iowa, United StatesKoen DeGeest - Oregon Health and Sciences University, United StatesLaila Damoush - Department of Pathology, University of Iowa, United StatesSamantha Aust - Department of Psychology, University of Iowa, United StatesAnil K Sood - Departments of Gynecologic Oncology, Cancer Biology, and Center for RNA Interference and Noncoding RNA, University of Texas, M.D. Anderson Cancer Center, United StatesSusan K Lutgendorf - Department of Psychology, University of Iowa, United States
- Resource Type
- Journal article
- Publication Details
- Brain, behavior, and immunity, Vol.50, pp.58-62
- DOI
- 10.1016/j.bbi.2015.04.019
- PMID
- 25989110
- PMCID
- PMC4631681
- NLM abbreviation
- Brain Behav Immun
- ISSN
- 0889-1591
- eISSN
- 1090-2139
- Publisher
- Elsevier Inc
- Grant note
- name: Carver Research Program of Excellence in Redox Biology and Medicine, award: CA140933, CA104825, CA109298, CA133114, CA182804, P30CA086862
- Language
- English
- Date published
- 11/2015
- Academic Unit
- Psychological and Brain Sciences; Pathology; Iowa Neuroscience Institute; Radiation Oncology; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984002336902771
Metrics
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