Journal article
Biochanin A Inhibits Breast Cancer Tumor Growth in A Murine Xenograft Model
Pharmaceutical research, Vol.25(9), pp.2158-2163
09/2008
DOI: 10.1007/s11095-008-9583-6
PMID: 18454305
Abstract
Our objective was to determine the effect of the flavonoid biochanin A (BCA), administered alone or in combination with the flavonoids quercetin and epigallocatechin-3-gallate (EGCG), on the growth of human breast cancer MCF-7 cells in a murine xenograft animal model.MCF-7 tumors were implanted into mice and groups of mice were treated with vehicle, BCA at 2 doses (5 or 15 mg/kg), quercetin and EGCG (5 mg/kg each), or BCA combined with quercetin and EGCG (5 mg/kg each). The flavonoids were injected once daily intraperitoneally, with treatment starting 4 weeks prior to cell inoculation.Treatment with 15 mg/kg of BCA or the mixture of the 3 flavonoids resulted in a reduction in tumor incidence. Tumor size in xenograft mice treated with 15 mg/kg BCA was significantly smaller than in the control group. Although quercetin/EGCG administration did not affect tumor size, treatment with the mixture of the 3 flavonoids at doses of 5 mg/kg produced similar effects as seen with 15 mg/kg BCA.Our findings indicate that BCA inhibits tumor growth in a xenograft animal model; BCA may represent a breast cancer preventive agent, either administered alone or in combination with other flavonoids.
Details
- Title: Subtitle
- Biochanin A Inhibits Breast Cancer Tumor Growth in A Murine Xenograft Model
- Creators
- Young Moon - Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences University at Buffalo, State University of New York 517 Hochstetter Hall Amherst New York 14260-1200 USABeom Shin - College of Pharmacy Catholic University of Daegu 330 Geumnak 1-ri, Hayang-eup, Gyeongsan-si Gyeongbuk 712-702 South KoreaGuohua An - Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences University at Buffalo, State University of New York 517 Hochstetter Hall Amherst New York 14260-1200 USAMarilyn Morris - Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences University at Buffalo, State University of New York 517 Hochstetter Hall Amherst New York 14260-1200 USA
- Resource Type
- Journal article
- Publication Details
- Pharmaceutical research, Vol.25(9), pp.2158-2163
- Publisher
- Springer US; Boston
- DOI
- 10.1007/s11095-008-9583-6
- PMID
- 18454305
- ISSN
- 0724-8741
- eISSN
- 1573-904X
- Language
- English
- Date published
- 09/2008
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984065502602771
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