Journal article
Biodegradable particles as vaccine antigen delivery systems for stimulating cellular immune responses
Human Vaccines & Immunotherapeutics, Vol.9(12), pp.2584-2590
12/24/2013
DOI: 10.4161/hv.26136
PMCID: PMC4162053
PMID: 23978910
Abstract
There is a need for both new and improved vaccination formulations for a range of diseases for which current vaccines are either inadequate or non-existent. Biodegradable polymer-based vaccines fulfill many of the desired properties in achieving effective long-term protection in a manner that is safe, economical, and potentially more practicable on a global scale. Here we discuss some of the work performed with micro/nanoparticles made from either synthetic (poly[lactic-co-glycolic acid] [PLGA] and polyanhydrides) or natural (chitosan) biodegradable polymers. Our attention is focused on, but not limited to, the generation of antitumor immunity where we stress the importance of particle size and co-delivery of antigen and adjuvant.
Details
- Title: Subtitle
- Biodegradable particles as vaccine antigen delivery systems for stimulating cellular immune responses
- Creators
- Vijaya B JoshiSean M GearyAliasger K Salem
- Resource Type
- Journal article
- Publication Details
- Human Vaccines & Immunotherapeutics, Vol.9(12), pp.2584-2590
- DOI
- 10.4161/hv.26136
- PMID
- 23978910
- PMCID
- PMC4162053
- NLM abbreviation
- Hum Vaccin Immunother
- ISSN
- 2164-5515
- eISSN
- 2164-554X
- Publisher
- Taylor & Francis
- Language
- English
- Date published
- 12/24/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering
- Record Identifier
- 9983985863602771
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