Journal article
Biodistribution of bone marrow mononuclear cells in chronic chagasic cardiomyopathy after intracoronary injection
International journal of cardiology, Vol.149(3), pp.310-314
06/16/2011
DOI: 10.1016/j.ijcard.2010.02.008
PMID: 20199816
Abstract
Background: Animal and human clinical studies have indicated that bone marrow (BM) mononuclear cell (MNC) therapy for Chagasic Cardiomyopathy (ChC) is feasible, safe and potentially efficacious. Nevertheless, little is known about the retention of these cells after intracoronary (IC) infusion.
Methods: Our study investigated the homing of technetium-99m (Tc-99m) labeled BM MNCs and compared it to thallium-201 (Tl-201) myocardial perfusion images using the standard 17-segment model. Six patients with congestive heart failure of chagasic etiology were included.
Results: Scintigraphic images revealed an uptake of 5.4% +/- 1.7, 4.3% +/- 1.5 and 2.3% +/- 0.6 of the total infused radioactivity in the heart after 1, 3 and 24 h, respectively. The remaining activity was distributed mainly to the liver and spleen. Of 102 segments analyzed, homing took place in 36%. Segments with perfusion had greater homing (58.6%) than those with decreased or no perfusion (6.8%), p<0.0001. There was no correlation between the number of injected cells and the number of segments with homing for each patient (r=-0.172, p=0.774).
Conclusions: These results indicate that Tc-99m-BM MNCs delivered by IC injection homed to the chagasic myocardium. However, cell biodistribution was heterogeneous and limited, being strongly associated with the myocardial perfusion pattern at rest. These initial data suggest that the IC route may present limitations in chagasic patients and that alternative routes of cell administration may be necessary. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
Details
- Title: Subtitle
- Biodistribution of bone marrow mononuclear cells in chronic chagasic cardiomyopathy after intracoronary injection
- Creators
- Lea Mirian Barbosa da Fonseca - Univ Fed Rio de Janeiro, Dept Radiol, Hosp Univ Clementino Fraga Filho, BR-21949913 Rio De Janeiro, BrazilSergio S. Xavier - Fundação Oswaldo CruzPaulo Henrique Rosado de Castro - Federal ReserveRonaldo S. L. Lima - Universidade Federal do Rio de JaneiroBianca Gutfilen - Universidade Federal do Rio de JaneiroRegina C. S. Goldenberg - Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Lab Cardiol Celular & Mol, BR-21941 Rio De Janeiro, BrazilAngelo Maiolino - Hospital Universitário Clementino Fraga FilhoClaudia L. R. Chagas - Universidade Federal do Rio de JaneiroRoberto C. Pedrosa - Universidade Federal do Rio de JaneiroAntonio Carlos Campos de Carvalho - Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Lab Cardiol Celular & Mol, BR-21941 Rio De Janeiro, Brazil
- Resource Type
- Journal article
- Publication Details
- International journal of cardiology, Vol.149(3), pp.310-314
- DOI
- 10.1016/j.ijcard.2010.02.008
- PMID
- 20199816
- NLM abbreviation
- Int J Cardiol
- ISSN
- 0167-5273
- eISSN
- 1874-1754
- Publisher
- Elsevier
- Number of pages
- 5
- Grant note
- Research Support Foundation of the State of Rio de Janeiro Brazilian National Council of Technological and Scientific Development
- Language
- English
- Date published
- 06/16/2011
- Academic Unit
- Radiology
- Record Identifier
- 9985143552902771
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