Journal article
Biodistribution of bone marrow mononuclear cells after intra-arterial or intravenous transplantation in subacute stroke patients
Regenerative medicine, Vol.8(2), pp.145-155
03/01/2013
DOI: 10.2217/RME.13.2
PMID: 23477395
Abstract
Aims: To assess the biodistribution of bone marrow mononuclear cells (BMMNC) delivered by different routes in patients with subacute middle cerebral artery ischemic stroke. Patients & methods: This was a nonrandomized, open-label Phase I clinical trial. After bone marrow harvesting, BMMNCs were labeled with technetium-99m and intra-arterially or intravenously delivered together with the unlabeled cells. Scintigraphies were carried out at 2 and 24 h after cell transplantation. Clinical follow-up was continued for 6 months. Results: Twelve patients were included, between 19 and 89 days after stroke, and received 1-5 x 10(8) BMMNCs. The intra-arterial group had greater radioactive counts in the liver and spleen and lower counts in the lungs at 2 and 24 h, while in the brain they were low and similar for both routes. Conclusion: BMMNC labeling with technetium-99m allowed imaging for up to 24 h after intra-arterial or intravenous injection in stroke patients.
Details
- Title: Subtitle
- Biodistribution of bone marrow mononuclear cells after intra-arterial or intravenous transplantation in subacute stroke patients
- Creators
- Paulo Henrique Rosado-de-Castro - Universidade Federal do Rio de JaneiroFelipe da Rocha Schmidt - Univ Fed Rio de Janeiro, Hosp Univ Clementino Fraga Filho, Neurol Serv, BR-21941913 Rio De Janeiro, BrazilValeria Battistella - Universidade Federal do Rio de JaneiroSergio Augusto Lopes de Souza - Univ Fed Rio de Janeiro, Ilha Fundao, Sch Med, Dept Radiol, BR-21941913 Rio De Janeiro, BrazilBianca Gutfilen - Universidade Federal do Rio de JaneiroRegina Coeli dos Santos Goldenberg - Universidade Federal do Rio de JaneiroTais Hanae Kasai-Brunswick - Universidade Federal do Rio de JaneiroLeandro Vairo - Universidade Federal do Rio de JaneiroRafaella Monteiro Silva - Hospital Universitário Clementino Fraga FilhoEduardo Wajnberg - Universidade Federal do Rio de JaneiroPedro Emmanuel Alvarenga Americano do Brasil - DOr Inst Res & Educ, Rio De Janeiro, BrazilEmerson Leandro Gasparetto - Universidade Federal do Rio de JaneiroAngelo Maiolino - Hospital Universitário Clementino Fraga FilhoSoniza Vieira Alves-Leon - Universidade Federal do Rio de JaneiroCharles Andre - Universidade Federal do Rio de JaneiroRosalia Mendez-Otero - Universidade Federal do Rio de JaneiroGabriel Rodriguez de Freitas - Universidade Federal do Rio de JaneiroLea Mirian Barbosa da Fonseca - Univ Fed Rio de Janeiro, Ilha Fundao, Sch Med, Dept Radiol, BR-21941913 Rio De Janeiro, Brazil
- Resource Type
- Journal article
- Publication Details
- Regenerative medicine, Vol.8(2), pp.145-155
- DOI
- 10.2217/RME.13.2
- PMID
- 23477395
- NLM abbreviation
- Regen Med
- ISSN
- 1746-0751
- eISSN
- 1746-076X
- Publisher
- Taylor & Francis
- Number of pages
- 11
- Grant note
- Ministry of Health Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) CNPq; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) 110.776/2010 / Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ); Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ) Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq); Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)
- Language
- English
- Date published
- 03/01/2013
- Academic Unit
- Radiology
- Record Identifier
- 9985143553802771
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