Journal article
Biogenic Aldehyde-Mediated Mechanisms of Toxicity in Neurodegenerative Disease
Current opinion in toxicology, Vol.13, pp.16-21
02/2019
DOI: 10.1016/j.cotox.2018.12.002
PMCID: PMC6625780
PMID: 31304429
Abstract
Oxidative decomposition of several biomolecules produces reactive aldehydes. Monoamine neurotransmitters are enzymatically converted to aldehydes via monoamine oxidase followed by further metabolism such as carbonyl oxidation/reduction. Elevated levels of aldehyde intermediates are implicated as factors in several pathological conditions, including Parkinson's disease. The biogenic aldehydes produced from dopamine, norepinephrine and serotonin are known to be toxic, generate reactive oxygen species and/or cause aggregation of proteins such as α-synuclein. Polyunsaturated lipids undergo oxidative decomposition to produce biogenic aldehydes, including 4-hydroxy-2-nonenal and malondialdehyde. These lipid aldehydes, some including an α,β-unsaturated carbonyl, target important proteins such as α-synuclein, proteasome degradation and G-protein-coupled signaling. Overproduction of biogenic aldehydes is a hypothesized factor in neurodegeneration; preventing their formation or scavenging may provide means for neuroprotection.
Details
- Title: Subtitle
- Biogenic Aldehyde-Mediated Mechanisms of Toxicity in Neurodegenerative Disease
- Creators
- Brianna S Cagle - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, 115 South Grand Ave, Iowa City, IA 52242-1112, USARachel A Crawford - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, 115 South Grand Ave, Iowa City, IA 52242-1112, USAJonathan A Doorn - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, 115 South Grand Ave, Iowa City, IA 52242-1112, USA
- Resource Type
- Journal article
- Publication Details
- Current opinion in toxicology, Vol.13, pp.16-21
- DOI
- 10.1016/j.cotox.2018.12.002
- PMID
- 31304429
- PMCID
- PMC6625780
- NLM abbreviation
- Curr Opin Toxicol
- ISSN
- 2468-2934
- eISSN
- 2468-2020
- Publisher
- Netherlands
- Grant note
- P30 ES005605 / NIEHS NIH HHS T32 GM067795 / NIGMS NIH HHS R01 ES029035 / NIEHS NIH HHS R21 AG057006 / NIA NIH HHS
- Language
- English
- Date published
- 02/2019
- Academic Unit
- Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984065480302771
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