Journal article
Biogenic Amine Involvement in Pyrogenicity and Enhancement of Lethal Endotoxin Shock by Group A Streptococcal Pyrogenic Exotoxin
Proceedings of the Society for Experimental Biology and Medicine, Vol.162(2), pp.269-274
11/1979
DOI: 10.3181/00379727-162-40663
PMID: 42075
Abstract
Summary
Group A streptococcal pyrogenic exotoxin type C (SPE C) was shown to produce fever which in part depended upon norepinephrine and stimulation of α-adrenergic receptors. Intracisternal injection of norepinephrine into rabbits already showing fevers due to SPE C resulted in further heightened fevers. Pretreatment of animals with either α-methyl tyrosine to deplete norepinephrine stores or phenoxybenzamine to block α-receptors depressed SPE-induced pyrogenicity. Pretreatment of animals with P-chlorophenylalanine to deplete serotonin stores accentuated fevers due to SPE and giving serotonin intracisternally to rabbits with fevers resulted in a significant drop in body temperature. This indicated serotonin exerted a negative effect on SPE pyrogenicity. Isoproterenol and propranolol did not affect SPE C fever production. When used alone, none of the drugs prevented the capacity of SPE C to enhance lethal endotoxin shock. However, phenoxybenzamine in combination with fluid replacement increased the survival rate of rabbits. It is proposed that SPE C may alter the endotoxin detoxification system, thus allowing endotoxin to persist in the circulation producing shock.
This work was supported by USPHS Grant AI-06487 from the National Institute of Allergy and Infectious Diseases. Dr. Schlievert received stipend support from USPHS Training Grant HLI-07014 from the National Heart, Lung and Blood Institute.
Details
- Title: Subtitle
- Biogenic Amine Involvement in Pyrogenicity and Enhancement of Lethal Endotoxin Shock by Group A Streptococcal Pyrogenic Exotoxin
- Creators
- Patrick M SchlievertDennis W Watson
- Resource Type
- Journal article
- Publication Details
- Proceedings of the Society for Experimental Biology and Medicine, Vol.162(2), pp.269-274
- Publisher
- SAGE Publications; London, England
- DOI
- 10.3181/00379727-162-40663
- PMID
- 42075
- ISSN
- 0037-9727
- eISSN
- 1535-3699
- Language
- English
- Date published
- 11/1979
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984002390402771
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