Journal article
Biologic response modifiers: Indications, implications, and insights
Journal of allergy and clinical immunology, Vol.139(5), pp.1445-1456
05/2017
DOI: 10.1016/j.jaci.2017.02.013
PMID: 28263774
Abstract
The field of biologic immune modulators is currently mushrooming at a dizzying pace. Although most of these biologics are tested and approved for one or a few indications, their unanticipated side effects and off-label use have contributed significantly to our understanding of basic immune mechanisms, the involvement of cytokines in several apparently nonimmunologic diseases, and the importance of compartmentalized immune responses. In this review we attempt to give a bird's-eye view of the major biologics and to highlight insights and implications derived from their secondary effects and adverse reactions.
Details
- Title: Subtitle
- Biologic response modifiers: Indications, implications, and insights
- Creators
- Benjamin P Davis - Department of Internal Medicine, Division of Immunology, University of Iowa Hospitals and Clinics, Iowa City, IowaZuhair K Ballas - Department of Internal Medicine, Division of Immunology, University of Iowa and the Iowa City Veterans Administration, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of allergy and clinical immunology, Vol.139(5), pp.1445-1456
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.jaci.2017.02.013
- PMID
- 28263774
- ISSN
- 0091-6749
- eISSN
- 1097-6825
- Language
- English
- Date published
- 05/2017
- Academic Unit
- Stead Family Department of Pediatrics; Immunology; Internal Medicine
- Record Identifier
- 9984093367702771
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