Journal article
Biological mechanisms in the relationship between depression and heart disease
Neuroscience and Biobehavioral Reviews, Vol.26(8), pp.941-962
2002
DOI: 10.1016/S0149-7634(03)00003-4
PMID: 12667498
Abstract
Psychological depression is shown to be associated with several aspects of coronary artery disease (CAD), including arrhythmias, myocardial infarction, heart failure and sudden death. The physiological mechanisms accounting for this association are unclear. Hypothalamic–pituitary–adrenal dysregulation, diminished heart rate variability, altered blood platelet function and noncompliance with medial treatments have been proposed as mechanisms underlying depression and cardiovascular disease. Recent evidence also suggests that reduced baroreflex sensitivity, impaired immune function, chronic fatigue and the co-morbidity of depression and anxiety may be involved in the relationship between depression and cardiovascular dysregulation. An experimental strategy using animal models for investigating underlying physiological abnormalities in depression is presented. A key to understanding the bidirectional association between depression and heart disease is to determine whether there are common changes in brain systems that are associated with these conditions. Such approaches may hold promise for advancing our understanding of the interaction between this mood disorder and CAD.
Details
- Title: Subtitle
- Biological mechanisms in the relationship between depression and heart disease
- Creators
- Angela J Grippo - Department of Psychology, The University of Iowa, 11 Seashore Hall E, Iowa City, IA 52242-1407, USAAlan Kim Johnson - Department of Psychology, The University of Iowa, 11 Seashore Hall E, Iowa City, IA 52242-1407, USA
- Resource Type
- Journal article
- Publication Details
- Neuroscience and Biobehavioral Reviews, Vol.26(8), pp.941-962
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0149-7634(03)00003-4
- PMID
- 12667498
- ISSN
- 0149-7634
- eISSN
- 1873-7528
- Language
- English
- Date published
- 2002
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213424102771
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