Journal article
Biologically Active Polyketide Metabolites from an Undetermined Fungicolous Hyphomycete Resembling Cladosporium
Journal of natural products (Washington, D.C.), Vol.65(6), pp.876-882
06/28/2002
DOI: 10.1021/np020097y
PMID: 12088431
Abstract
Eight new polyketide-derived metabolites [cladoacetals A and B (1 and 2), 3-(2-formyl-3-hydroxyphenyl)-propionic acid (3), 3-deoxyisoochracinic acid (4), isoochracinol (5), 7-hydroxy-3-(2,3-dihydroxybutyl)-1(3H)-isobenzofuranone (6), (+)-cyclosordariolone (10), and altersolanol J (11)] and six known metabolites [two isomeric 1-(1,3-dihydro-4-hydroxy-1-isobenzofuranyl)butan-2,3-diols (7a/b), 7-hydroxy-1(3H)-isobenzo-furanone (8), isoochracinic acid (9), altersolanol A (12), and macrosporin (13)] have been isolated from solid-substrate fermentation cultures of an undetermined fungicolous isolate (NRRL 29097) that resembles Cladosporium sp. All structures were assigned primarily by analysis of 1D and/or 2D NMR data. Five of the compounds showed antibacterial activity.
Details
- Title: Subtitle
- Biologically Active Polyketide Metabolites from an Undetermined Fungicolous Hyphomycete Resembling Cladosporium
- Creators
- Ulrich HöLLER - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, and Mycotoxin Research Unit, Agricultural ResearchService, National Center for Agricultural Utilization Research, United States Department of Agriculture, Peoria, Illinois 61604James B Gloer - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, and Mycotoxin Research Unit, Agricultural ResearchService, National Center for Agricultural Utilization Research, United States Department of Agriculture, Peoria, Illinois 61604Donald T Wicklow - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, and Mycotoxin Research Unit, Agricultural ResearchService, National Center for Agricultural Utilization Research, United States Department of Agriculture, Peoria, Illinois 61604
- Resource Type
- Journal article
- Publication Details
- Journal of natural products (Washington, D.C.), Vol.65(6), pp.876-882
- Publisher
- American Chemical Society
- DOI
- 10.1021/np020097y
- PMID
- 12088431
- ISSN
- 0163-3864
- eISSN
- 1520-6025
- Language
- English
- Date published
- 06/28/2002
- Academic Unit
- Chemistry
- Record Identifier
- 9984216696702771
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