Journal article
Biologically active biotin derivatives of schweinfurthin F
Bioorganic & medicinal chemistry letters, Vol.20(22), pp.6716-6720
2010
DOI: 10.1016/j.bmcl.2010.08.143
PMID: 20869871
Abstract
As a prelude to efforts to identify schweinfurthin binding proteins, an ester conjugate and an amide conjugate of schweinfurthin F and biotin have been prepared by chemical synthesis. These compounds maintain activity in SF-295 cells comparable to the parent system, and display the lower potency in A549 cells that is a characteristic of the schweinfurthin pattern of activity.
Details
- Title: Subtitle
- Biologically active biotin derivatives of schweinfurthin F
- Creators
- Natalie C Ulrich - Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, United StatesCraig H Kuder - Department of Pharmacology, University of Iowa, Iowa City, IA 52242-1294, United StatesRaymond J Hohl - Department of Pharmacology, University of Iowa, Iowa City, IA 52242-1294, United StatesDavid F Wiemer - Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, United States
- Resource Type
- Journal article
- Publication Details
- Bioorganic & medicinal chemistry letters, Vol.20(22), pp.6716-6720
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.bmcl.2010.08.143
- PMID
- 20869871
- ISSN
- 0960-894X
- eISSN
- 1464-3405
- Grant note
- DOI: 10.13039/100001024, name: Roy J. Carver Charitable Trust
- Language
- English
- Date published
- 2010
- Academic Unit
- Neuroscience and Pharmacology; Chemistry; Internal Medicine
- Record Identifier
- 9983985859202771
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