Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy

Scott M Ebert; Blake B Rasmussen; Andrew R Judge; Sarah M Judge; Lars Larsson; Ronald C Wek; Tracy G Anthony; George R Marcotte; Matthew J Miller; Mark A Yorek; Adrian Vella; Elena Volpi; Jennifer I Stern; Matthew D Strub; Zachary Ryan; John J Talley; Christopher M Adams

doi:10.1093/jn/nxab440

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Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy

Journal article

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Peer reviewed

Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy

Scott M Ebert, Blake B Rasmussen, Andrew R Judge, Sarah M Judge, Lars Larsson, Ronald C Wek, Tracy G Anthony, George R Marcotte, Matthew J Miller, Mark A Yorek, …

The Journal of nutrition, Vol.152(4), pp.926-938

04/01/2022

DOI: 10.1093/jn/nxab440

PMCID: PMC8970988

PMID: 34958390

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Abstract

Activating transcription factor 4 (ATF4) is a multifunctional transcription regulatory protein in the basic leucine zipper superfamily. ATF4 can be expressed in most if not all mammalian cell types, and it can participate in a variety of cellular responses to specific environmental stresses, intracellular derangements, or growth factors. Because ATF4 is involved in a wide range of biological processes, its roles in human health and disease are not yet fully understood. Much of our current knowledge about ATF4 comes from investigations in cultured cell models, where ATF4 was originally characterized and where further investigations continue to provide new insights. ATF4 is also an increasingly prominent topic of in vivo investigations in fully differentiated mammalian cell types, where our current understanding of ATF4 is less complete. Here, we review some important high-level concepts and questions concerning the basic biology of ATF4. We then discuss current knowledge and emerging questions about the in vivo role of ATF4 in one fully differentiated cell type, mammalian skeletal muscle fibers.

Cell Differentiation

Activating Transcription Factor 4 - genetics

Activating Transcription Factor 4 - metabolism

Animals

Biology

Humans

Mammals

Muscle Fibers, Skeletal - metabolism

Muscular Atrophy - etiology

Details

Title: Subtitle: Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy
Creators: Scott M Ebert - Mayo Clinic
Blake B Rasmussen - Emmyon, Inc., Rochester, MN.
Andrew R Judge - Emmyon, Inc., Rochester, MN.
Sarah M Judge - University of Florida
Lars Larsson - Karolinska Institutet
Ronald C Wek - Indiana University – Purdue University Indianapolis
Tracy G Anthony - Rutgers, The State University of New Jersey
George R Marcotte - Mayo Clinic
Matthew J Miller - Mayo Clinic
Mark A Yorek - University of Iowa
Adrian Vella - Mayo Clinic, Rochester, MN.
Elena Volpi - The University of Texas Medical Branch at Galveston
Jennifer I Stern - Mayo Clinic, Rochester, MN.
Matthew D Strub - Mayo Clinic
Zachary Ryan - Mayo Clinic, Rochester, MN.
John J Talley - Emmyon, Inc., Rochester, MN.
Christopher M Adams - Mayo Clinic
Resource Type: Journal article
Publication Details: The Journal of nutrition, Vol.152(4), pp.926-938
DOI: 10.1093/jn/nxab440
PMID: 34958390
PMCID: PMC8970988
NLM abbreviation: J Nutr
ISSN: 0022-3166
eISSN: 1541-6100
Grant note: I01 BX000976 / BLRD VA P30 AG024832 / NIA NIH HHS R01 AG060637 / NIA NIH HHS T32 GM139776 / NIGMS NIH HHS R01 DK126206 / NIDDK NIH HHS R01 DK109714 / NIDDK NIH HHS R01 AR071762 / NIAMS NIH HHS
Language: English
Date published: 04/01/2022
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984359954502771

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