Journal article
Biology of HIV mucosal transmission
Current opinion in HIV & AIDS, Vol.3(5), pp.534-540
09/2008
DOI: 10.1097/COH.0b013e32830634c6
PMCID: PMC2542876
PMID: 18802490
Abstract
HIV-1 mucosal transmission plays a critical role in HIV-1 infection and AIDS pathogenesis. This review summarizes the latest advances in biological studies of HIV-1 mucosal transmission, highlighting the implications of these studies in the development of microbicides to prevent HIV-1 transmission.
New studies of initial HIV-1 infection using improved culture models updated the current view of mucosal transmission. Mechanistic studies enhanced our understanding of cell-cell transmission of HIV-1 mediated by the major target cells, including dendritic cells, CD4(+) T cells, and macrophages. Increasing evidence indicated the significance of host factors and immune responses in HIV-1 mucosal infection and transmission.
Recent progress in HIV-1 mucosal infection and transmission enriches our knowledge of virus-host interactions and viral pathogenesis. Functional studies of HIV-1 interactions with host cells can provide new insights into the design of more effective approaches to combat HIV-1 infection and AIDS.
Details
- Title: Subtitle
- Biology of HIV mucosal transmission
- Creators
- Li Wu - Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. liwu@mcw.edu
- Resource Type
- Journal article
- Publication Details
- Current opinion in HIV & AIDS, Vol.3(5), pp.534-540
- DOI
- 10.1097/COH.0b013e32830634c6
- PMID
- 18802490
- PMCID
- PMC2542876
- NLM abbreviation
- Curr Opin HIV AIDS
- ISSN
- 1746-630X
- eISSN
- 1746-6318
- Publisher
- United States
- Grant note
- R01 AI068493-03 / NIAID NIH HHS R01 AI068493 / NIAID NIH HHS
- Language
- English
- Date published
- 09/2008
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984001160802771
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