Journal article
Biomarker-assessed total energy intake and its cohort study association with all-cause mortality in postmenopausal females
The American journal of clinical nutrition, Vol.119(5), pp.1329-1337
05/2024
DOI: 10.1016/j.ajcnut.2024.02.020
PMCID: PMC11130702
PMID: 38428741
Abstract
The association of total energy intake (EI) with all-cause mortality is uncertain, as are the dependencies of this association on age and weight change history.
To identify an EI biomarker suitable for use in epidemiologic association studies, and to study EI associations with total mortality in a Women's Health Initiative (WHI) cohort of postmenopausal U.S. females (1993-present).
EI biomarkers were developed based on doubly-labeled water (DLW) total energy expenditure (TEE) and weight variation during the two-week DLW protocol period using the energy balance method, in an embedded feeding study (n=153). This along with two earlier WHI nutrition biomarker studies having TEE assessments (n=1131 total), with 14.6 years (median) follow-up, constituted a prospective cohort for the study of EI and all-cause mortality.
An empirical biomarker for log (EI) was developed that had a correlation of 0.73 with log (feeding study-consumed EI). The overall association between EI and mortality was non-significant. The association, however, depended on age (P=0.009) with lower EI associated with lower mortality at younger ages, and also on preceding weight change history (P=0.03). Among participants with stable or increasing weight, mortality hazard ratios (HRs) (95% CIs) for a 12% lower EI were 0.66 (0.51, 0.87) at age 60, 0.84 (0.72, 0.98) at age 70, and 1.06 (0.87, 1.29) at age 80. Corresponding values for participants having preceding weight loss were 0.83 (0.61, 1.12) at age 60, 1.05 (0.87 1.26) at age 70, and 1.33 (1.08, 1.63) at age 80. A previously considered EI biomarker, using a theoretical model for variation in body fat- and fat free-mass components over time, gave similar results following rescaling.
Lower EI is associated with lower all-cause mortality among younger postmenopausal females with stable or increasing weight, and with higher mortality risk among older females with weight loss. This study is registered with clinicaltrials.gov identifier: NCT00000611.
Details
- Title: Subtitle
- Biomarker-assessed total energy intake and its cohort study association with all-cause mortality in postmenopausal females
- Creators
- Ross L Prentice - Fred Hutch Cancer CenterAaron K Aragaki - Fred Hutch Cancer CenterCheng Zheng - University of Nebraska Medical CenterJoAnn E Manson - Brigham and Women's HospitalLesley F Tinker - Fred Hutch Cancer CenterMichele N Ravelli - University of Wisconsin–MadisonYasmin Mossavar-Rahmani - Albert Einstein College of MedicineRobert B Wallace - University of IowaJanet A Tooze - Wake Forest UniversityKaren C Johnson - University of Tennessee at KnoxvilleJohanna W Lampe - Fred Hutch Cancer CenterMarian L Neuhouser - Fred Hutch Cancer CenterDale A Schoeller - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- The American journal of clinical nutrition, Vol.119(5), pp.1329-1337
- DOI
- 10.1016/j.ajcnut.2024.02.020
- PMID
- 38428741
- PMCID
- PMC11130702
- NLM abbreviation
- Am J Clin Nutr
- eISSN
- 1938-3207
- Grant note
- DOI: 10.13039/100000016, name: U.S. Department of Health and Human Services, award: HHSN268202100003C, HHSN268202100001C, HHSN268202100046C, HHSN271202100004C, HHSN268202100004C, HHSN268202100002C; DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000050, name: National Heart Lung and Blood Institute, award: HHSN271202100004C, HHSN268202100003C; DOI: 10.13039/100000054, name: National Cancer Institute, award: R01 CA119171, P30 CA015704
- Language
- English
- Electronic publication date
- 02/28/2024
- Date published
- 05/2024
- Academic Unit
- Epidemiology; Injury Prevention Research Center
- Record Identifier
- 9984563459902771
Metrics
13 Record Views