Journal article
Biomarker-calibrated energy and protein consumption and increased cancer risk among postmenopausal women
American journal of epidemiology, Vol.169(8), pp.977-989
04/15/2009
DOI: 10.1093/aje/kwp008
PMCID: PMC2732977
PMID: 19258487
Abstract
The authors previously reported equations, derived from the Nutrient Biomarker Study within the Women's Health Initiative, that produce calibrated estimates of energy, protein, and percentage of energy from protein consumption from corresponding food frequency questionnaire estimates and data on other factors, such as body mass index, age, and ethnicity. Here, these equations were applied to yield calibrated consumption estimates for 21,711 women enrolled in the Women's Health Initiative dietary modification trial comparison group and 59,105 women enrolled in the observational study. These estimates were related prospectively to total and site-specific invasive cancer incidence (1993-2005). In combined cohort analyses that do not control for body mass, uncalibrated energy was not associated with total cancer incidence or site-specific cancer incidence for most sites, whereas biomarker-calibrated energy was positively associated with total cancer (hazard ratio = 1.18, 95% confidence interval: 1.10, 1.27, for 20% consumption increase), as well as with breast, colon, endometrial, and kidney cancer (respective hazard ratios of 1.24, 1.35, 1.83, and 1.47). Calibrated protein was weakly associated, and calibrated percentage of energy from protein was inversely associated, with total cancer. Calibrated energy and body mass index associations were highly interdependent. Implications for the interpretation of nutritional epidemiology studies are described.
Details
- Title: Subtitle
- Biomarker-calibrated energy and protein consumption and increased cancer risk among postmenopausal women
- Creators
- Ross L Prentice - Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA. rprentic@fhcrc.orgPamela A ShawSheila A BinghamShirley A A BeresfordBette CaanMarian L NeuhouserRuth E PattersonMarcia L StefanickSuzanne SatterfieldCynthia A ThomsonLinda SnetselaarAsha ThomasLesley F Tinker
- Resource Type
- Journal article
- Publication Details
- American journal of epidemiology, Vol.169(8), pp.977-989
- Publisher
- United States
- DOI
- 10.1093/aje/kwp008
- PMID
- 19258487
- PMCID
- PMC2732977
- ISSN
- 1476-6256
- eISSN
- 1476-6256
- Grant note
- R01 CA119171 / NCI NIH HHS N01WH32122 / WHI NIH HHS MC_U105630924 / Medical Research Council P01 CA053996 / NCI NIH HHS N01WH32100-2 / WHI NIH HHS N01WH32118-19 / WHI NIH HHS N01WH32115 / WHI NIH HHS N01WH32108-9 / WHI NIH HHS CA53996 / NCI NIH HHS N01WH24152 / WHI NIH HHS N01WH42129-32 / WHI NIH HHS N01WH42107-26 / WHI NIH HHS N01WH44221 / WHI NIH HHS N01WH22110 / WHI NIH HHS N01WH32111-13 / WHI NIH HHS N01WH32105-6 / WHI NIH HHS
- Language
- English
- Date published
- 04/15/2009
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9983995022402771
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