Journal article
Biomarkers of Drug-Induced Kidney Toxicity
Therapeutic drug monitoring, Vol.41(2), pp.213-226
04/01/2019
DOI: 10.1097/FTD.0000000000000589
PMCID: PMC6436396
PMID: 30883514
Abstract
Blood urea nitrogen and serum creatinine are imperfect markers of kidney function because they are influenced by many renal and nonrenal factors independent of kidney function. A biomarker that is released directly into the blood or urine by the kidney in response to injury may be a better early marker of drug-induced kidney toxicity than blood urea nitrogen and serum creatinine. Urine albumin and urine protein, as well as urinary markers kidney injury molecule-1 (KIM-1), beta 2-microglobulin (B2M), cystatin C, clusterin, and trefoil factor-3 (TFF-3) have been accepted by the Food and Drug Administration and European Medicines Agency as highly sensitive and specific urinary biomarkers to monitor drug-induced kidney injury in preclinical studies and on a case-by-case basis in clinical trials. Other biomarkers of drug-induced kidney toxicity that have been detected in the urine of rodents or patients include IL-18, neutrophil gelatinase-associated lipocalin, netrin-1, liver-type fatty acid-binding protein (L-FABP), urinary exosomes, and TIMP2 (insulin-like growth factor-binding protein 7)/IGFBP7 (insulin-like growth factor-binding protein 7), also known as NephroCheck, the first Food and Drug Administration-approved biomarker testing platform to detect acute kidney injury in patients. In the future, a combined use of functional and damage markers may advance the field of biomarkers of drug-induced kidney toxicity. Earlier detection of drug-induced kidney toxicity with a kidney-specific biomarker may result in the avoidance of nephrotoxic agents in clinical studies and may allow for earlier intervention to repair damaged kidneys.
Details
- Title: Subtitle
- Biomarkers of Drug-Induced Kidney Toxicity
- Creators
- Benjamin R. Griffin - University of Colorado DenverSarah Faubel - University of Colorado DenverCharles L. Edelstein - University of Colorado Denver
- Resource Type
- Journal article
- Publication Details
- Therapeutic drug monitoring, Vol.41(2), pp.213-226
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/FTD.0000000000000589
- PMID
- 30883514
- PMCID
- PMC6436396
- ISSN
- 0163-4356
- eISSN
- 1536-3694
- Number of pages
- 14
- Grant note
- 1I01BX001737-01A1 / Veterans Affairs Merit Award; US Department of Veterans Affairs
- Language
- English
- Date published
- 04/01/2019
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984359921402771
Metrics
18 Record Views