Biomarkers of Incident Radiographic Knee Osteoarthritis: Do They Vary by Chronic Knee Symptoms?

Yvonne M Golightly; Stephen W Marshall; Virginia B Kraus; Jordan B Renner; Andres Villaveces; Carri Casteel; Joanne M Jordan

doi:10.1002/art.30412

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Biomarkers of Incident Radiographic Knee Osteoarthritis: Do They Vary by Chronic Knee Symptoms?

Journal article

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Peer reviewed

Biomarkers of Incident Radiographic Knee Osteoarthritis: Do They Vary by Chronic Knee Symptoms?

Yvonne M Golightly, Stephen W Marshall, Virginia B Kraus, Jordan B Renner, Andres Villaveces, Carri Casteel and Joanne M Jordan

Arthritis and rheumatism, Vol.63(8), pp.2276-2283

2011

DOI: 10.1002/art.30412

PMCID: PMC3149729

PMID: 21506100

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Abstract

Objective To explore the ability of osteoarthritis (OA)-related biomarkers to predict incident radiographic knee OA in a large sample of African American and Caucasian men and women. Methods Baseline levels of serum cartilage oligomeric matrix protein (COMP), hyaluronan (HA), high-sensitivity C-reactive protein (hsCRP), and keratan sulfate (KS) and baseline and followup radiographs were available for 353 knees without baseline osteophyte formation and for 446 knees without baseline joint space narrowing (JSN). Cox models estimated the hazard ratio (HR) and 95% confidence interval (95% CI) for incident knee OA for a 1-unit increase in the ln of each biomarker, with adjustment for age, race, sex, body mass index, and knee OA of the contralateral limb. Report of chronic knee symptoms was explored as a modifier of the association. Results The hazard of incident knee osteophytes (HR 2.16 [95% CI 1.39-3.37]) and incident JSN (HR 1.82 [95% CI 1.15-2.89]) increased with higher baseline ln(COMP) levels. The hazard of incident knee JSN increased with higher ln(HA) levels (HR 1.46 [95% CI 1.14-1.87]). Baseline ln(hsCRP) and ln(KS) did not predict incident knee outcomes. HRs per unit increase in ln(COMP), ln(HA), and ln(KS) were higher among knees with chronic symptoms than among those without symptoms. Conclusion Higher baseline ln(COMP) and ln(HA) levels were associated with incident knee OA over an average followup period of 6.3 years. These results represent detection of a molecular stage of OA prior to radiographic manifestations. Further exploration is needed to determine how chronic knee symptoms modify the biomarker-incident knee OA association. Copyright © 2011 by the American College of Rheumatology.

Osteoarthritis

Biological and medical sciences

Diseases of the osteoarticular system

Medical sciences

Miscellaneous. Osteoarticular involvement in other diseases

Details

Title: Subtitle: Biomarkers of Incident Radiographic Knee Osteoarthritis: Do They Vary by Chronic Knee Symptoms?
Creators: Yvonne M Golightly - University of North Carolina, Chapel Hill, United States
Stephen W Marshall - University of North Carolina, Chapel Hill, United States
Virginia B Kraus - Duke University Medical Center, Durham, North Carolina, United States
Jordan B Renner - University of North Carolina, Chapel Hill, United States
Andres Villaveces - University of North Carolina, Chapel Hill, United States
Carri Casteel - University of North Carolina, Chapel Hill, United States
Joanne M Jordan - University of North Carolina, Chapel Hill, United States
Resource Type: Journal article
Publication Details: Arthritis and rheumatism, Vol.63(8), pp.2276-2283
DOI: 10.1002/art.30412
PMID: 21506100
PMCID: PMC3149729
NLM abbreviation: Arthritis Rheum
ISSN: 0004-3591
eISSN: 1529-0131
Publisher: Wiley
Language: English
Date published: 2011
Academic Unit: Occupational and Environmental Health; Epidemiology; Injury Prevention Research Center
Record Identifier: 9984214814202771

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