Biomarkers of Injury Severity in Shoulder Instability and Posttraumatic Osteoarthritis

Patrick W. Rooney; Reilly Corken; Mark D. Wishman; Cory Call; Maria Bozoghlian; Carter Lane; Mitchell C. Coleman; James V. Nepola; Brendan M. Patterson; Joseph W. Galvin

doi:10.2106/JBJS.OA.25.00351

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Biomarkers of Injury Severity in Shoulder Instability and Posttraumatic Osteoarthritis

Journal article

Peer reviewed

Biomarkers of Injury Severity in Shoulder Instability and Posttraumatic Osteoarthritis

Patrick W. Rooney, Reilly Corken, Mark D. Wishman, Cory Call, Maria Bozoghlian, Carter Lane, Mitchell C. Coleman, James V. Nepola, Brendan M. Patterson and Joseph W. Galvin

JB & JS open access, Vol.11(2), e25.00351

04/2026

DOI: 10.2106/JBJS.OA.25.00351

PMID: 42099885

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Abstract

» There is a poor understanding of the significance of biomarkers in the blood, synovial fluid, and tissue in patients with shoulder instability and posttraumatic osteoarthritis (PTOA). » Identification of biomarkers associated with injury severity in shoulder instability may provide prognostic information to help guide surgical treatment algorithms. » Current evidence suggests that the biomarkers of periostin, tumor necrosis factor-alpha, IL1B, and cartilage oligomeric matrix protein are associated with injury severity in patients with recurrent anterior shoulder instability. » There is limited information on genetic, transcriptomic, and protein biomarkers which may indicate individuals who are at more risk for development of shoulder instability. » An improved understanding of the local biomolecular tissue response to first-time and recurrent anterior shoulder instability may contribute to the development of novel therapeutic strategies for gene and protein targets to halt the early cascade of PTOA.

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Details

Title: Subtitle: Biomarkers of Injury Severity in Shoulder Instability and Posttraumatic Osteoarthritis
Creators: Patrick W. Rooney - Madigan Army Medical Center
Reilly Corken - University of Iowa Hospitals and Clinics
Mark D. Wishman - University of Iowa
Cory Call - University of Iowa Hospitals and Clinics
Maria Bozoghlian - University of Iowa Hospitals and Clinics
Carter Lane - University of Iowa Hospitals and Clinics
Mitchell C. Coleman - University of Iowa Hospitals and Clinics
James V. Nepola - University of Iowa Hospitals and Clinics
Brendan M. Patterson - University of Iowa Hospitals and Clinics
Joseph W. Galvin - University of Iowa Hospitals and Clinics
Resource Type: Journal article
Publication Details: JB & JS open access, Vol.11(2), e25.00351
DOI: 10.2106/JBJS.OA.25.00351
PMID: 42099885
ISSN: 2472-7245
eISSN: 2472-7245
Publisher: Wolters Kluwer Health
Language: English
Date published: 04/2026
Academic Unit: Orthopedics and Rehabilitation; Internal Medicine
Record Identifier: 9985161450202771

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