Journal article
Biomarkers of fatty acids and risk of type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies
Critical reviews in food science and nutrition, Vol.61(16), pp.2705-2718
09/08/2021
DOI: 10.1080/10408398.2020.1784839
PMID: 32598176
Abstract
We aimed to quantify and generate comprehensive evidence on the associations of different fatty acids (FAs) with the risk of type 2 diabetes mellitus (T2DM). PubMed, MEDLINE, and Embase were searched for prospective cohort studies that examined the association between FA biomarkers and the risk of T2DM published before 18 May 2020. Random-effects meta-analyses of the effects of FA concentration on T2DM were performed. Thirty-three studies involving 95,810 adults (19,904 cases) were included. Divergent associations of different types of FAs with type 2 diabetes were observed. The pooled relative risk (RRs) of T2DM comparing the top versus the bottom tertile of saturated FAs (C14:0, C16:0, C18:0, total saturated FAs), monounsaturated FA (C16:1 n-7), polyunsaturated FA (C20:3 n-6, C22:4 n-6), and Δ-6-desaturase activities ranged from 1.19 to 1.80. Interestingly, unlike previous studies, we found a negative correlation between odd-chain saturated FAs (C15:0, C17:0), trans-FAs (trans-C16:1 n-7), total n-6, Δ-5-desaturase activities and risk of T2DM. The pooled RRs of T2DM comparing the top versus the bottom tertile of these FAs ranged from 0.62 to 0.78. No associations with T2DM were observed for the other FAs. Considerable heterogeneity was observed in our study, and no definitive conclusions can be made until further investigation has been carried out.
Details
- Title: Subtitle
- Biomarkers of fatty acids and risk of type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies
- Creators
- Gengdong Chen - Department of Obstetrics, Foshan Institute of Fetal Medicine, Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical UniversityYan Li - Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical UniversityFangfang Zeng - Department of Epidemiology, School of Medicine, Jinan UniversityGuifang Deng - Department of Clinical Nutrition, Nanshan People's HospitalJingjing Liang - Guangzhou Medical UniversityJue Wang - Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical UniversityYixiang Su - Sun Yat-sen UniversityYuming Chen - Sun Yat-sen UniversityLimei Mao - Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical UniversityZhengping Liu - Department of Obstetrics, Foshan Institute of Fetal Medicine, Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical UniversityWei Bao - University of IowaZheqing Zhang - Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University
- Resource Type
- Journal article
- Publication Details
- Critical reviews in food science and nutrition, Vol.61(16), pp.2705-2718
- Publisher
- Taylor & Francis
- DOI
- 10.1080/10408398.2020.1784839
- PMID
- 32598176
- ISSN
- 1040-8398
- eISSN
- 1549-7852
- Grant note
- DOI: 10.13039/501100001809, name: National Natural Science Foundation of China, award: 81502798; name: Natural Science Foundation of Guangdong Province, China, award: 2015A030310399; name: Basic and Applied Basic Research Foundation of Guangdong Province, award: 2019A1515110163; name: Foundation of Bureau of Science and Technology of Foshan City, award: 1920001000294
- Language
- English
- Date published
- 09/08/2021
- Academic Unit
- Epidemiology
- Record Identifier
- 9984364367902771
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