Journal article
Biomarkers of ketamine’s antidepressant effect: a clinical review of genetics, functional connectivity, and neurophysiology
Chronic stress (Thousand Oaks, Calif.), Vol.5, p.247054702110142
01/2021
DOI: 10.1177/24705470211014210
PMCID: PMC8186113
PMID: 34159281
Abstract
Major depressive disorder (MDD) is one of the leading causes of morbidity and all-cause mortality (including suicide) worldwide, and, unfortunately, first-line monoaminergic antidepressants and evidence-based psychotherapies are not effective for all patients. Subanesthetic doses of the N-methyl-D-aspartate receptor antagonists and glutamate modulators ketamine and S-ketamine have rapid and robust antidepressant efficacy in such treatment-resistant depressed patients (TRD). Yet, as with all antidepressant treatments including electroconvulsive therapy (ECT), not all TRD patients adequately respond, and we are presently unable to a priori predict who will respond or not respond to ketamine. Therefore, antidepressant treatment response biomarkers to ketamine have been a major focus of research for over a decade. In this article, we review the evidence in support of treatment response biomarkers, with a particular focus on genetics, functional magnetic resonance imaging, and neurophysiological studies, i.e. electroencephalography and magnetoencephalography. The studies outlined here lay the groundwork for replication and dissemination.
Details
- Title: Subtitle
- Biomarkers of ketamine’s antidepressant effect: a clinical review of genetics, functional connectivity, and neurophysiology
- Creators
- Alexandra A Alario - Department of Psychiatry and Iowa Neuroscience Institute, University of Iowa Health Care, Iowa City, IA, USAMark J Niciu - Department of Psychiatry and Iowa Neuroscience Institute, University of Iowa Health Care, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Chronic stress (Thousand Oaks, Calif.), Vol.5, p.247054702110142
- DOI
- 10.1177/24705470211014210
- PMID
- 34159281
- PMCID
- PMC8186113
- ISSN
- 2470-5470
- eISSN
- 2470-5470
- Language
- English
- Date published
- 01/2021
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984082700302771
Metrics
20 Record Views