Journal article
Biomaterials with structural hierarchy and controlled 3D nanotopography guide endogenous bone regeneration
Science advances, Vol.7(31), eabg3089
07/01/2021
DOI: 10.1126/sciadv.abg3089
PMCID: PMC8318363
PMID: 34321208
Abstract
Biomaterials without exogenous cells or therapeutic agents often fail to achieve rapid endogenous bone regeneration with high quality. Here, we reported a class of three-dimensional (3D) nanofiber scaffolds with hierarchical structure and controlled alignment for effective endogenous cranial bone regeneration. 3D scaffolds consisting of radially aligned nanofibers guided and promoted the migration of bone marrow stem cells from the surrounding region to the center in vitro. These scaffolds showed the highest new bone volume, surface coverage, and mineral density among the tested groups in vivo. The regenerated bone exhibited a radially aligned fashion, closely recapitulating the scaffold's architecture. The organic phase in regenerated bone showed an aligned, layered, and densely packed structure, while the inorganic mineral phase showed a uniform distribution with smaller pore size and an even distribution of stress upon the simulated compression. We expect that this study will inspire the design of next-generation biomaterials for effective endogenous bone regeneration with desired quality.
Details
- Title: Subtitle
- Biomaterials with structural hierarchy and controlled 3D nanotopography guide endogenous bone regeneration
- Creators
- Shixuan Chen - University of Nebraska Medical CenterHongjun Wang - University of Nebraska Medical CenterValerio Luca Mainardi - Politecnico di MilanoGiuseppe Talo - Istituto Ortopedico GaleazziAlec McCarthy - University of Nebraska Medical CenterJohnson John - University of Nebraska Medical CenterMatthew J. Teusink - University of Nebraska Medical CenterLiu Hong - University of IowaJingwei Xie - University of Nebraska Medical Center
- Resource Type
- Journal article
- Publication Details
- Science advances, Vol.7(31), eabg3089
- DOI
- 10.1126/sciadv.abg3089
- PMID
- 34321208
- PMCID
- PMC8318363
- NLM abbreviation
- Sci Adv
- ISSN
- 2375-2548
- eISSN
- 2375-2548
- Publisher
- Amer Assoc Advancement Science
- Number of pages
- 14
- Grant note
- Nebraska Research Initiative R01GM123081; R01GM138552; P30GM127200 / National Institute of General Medical Science (NIGMS) at the NIH FY19 W81XWH2010207; NE LB606 / Congressionally Directed Medical Research Program (CDMRP)/Peer Reviewed Medical Research Program (PRMRP) University of Nebraska Medical Center (UNMC) 1R21DE027516 / National Institute of Dental and Craniofacial Research (NIDCR) at the NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR) P30GM127200 / Nebraska Center for Nanomedicine (NCN) Center for Biomedical Research Excellence (Institutional Development Award, NIGMS of the NIH) UNMC Office
- Language
- English
- Date published
- 07/01/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Prosthodontics; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984367759902771
Metrics
26 Record Views