Journal article
Biomimetic Mineralization of Biomaterials Using Simulated Body Fluids for Bone Tissue Engineering and Regenerative Medicine
Tissue engineering. Part A, Vol.23(19-20), pp.1169-1180
10/2017
DOI: 10.1089/ten.TEA.2016.0556
PMCID: PMC5653095
PMID: 28463603
Abstract
Development of synthetic biomaterials imbued with inorganic and organic characteristics of natural bone that are capable of promoting effective bone tissue regeneration is an ongoing goal of regenerative medicine. Calcium phosphate (CaP) has been predominantly utilized to mimic the inorganic components of bone, such as calcium hydroxyapatite, due to its intrinsic bioactivity and osteoconductivity. CaP-based materials can be further engineered to promote osteoinductivity through the incorporation of osteogenic biomolecules. In this study, we briefly describe the microstructure and the process of natural bone mineralization and introduce various methods for coating CaP onto biomaterial surfaces. In particular, we summarize the advantages and current progress of biomimetic surface-mineralizing processes using simulated body fluids for coating bone-like carbonated apatite onto various material surfaces such as metals, ceramics, and polymers. The osteoinductive effects of integrating biomolecules such as proteins, growth factors, and genes into the mineral coatings are also discussed.
Details
- Title: Subtitle
- Biomimetic Mineralization of Biomaterials Using Simulated Body Fluids for Bone Tissue Engineering and Regenerative Medicine
- Creators
- Kyungsup Shin - 1 Department of Orthodontics, College of Dentistry and Dental Clinics, University of Iowa , Iowa City, IowaTimothy Acri - 2 Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa , Iowa City, IowaSean Geary - 2 Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa , Iowa City, IowaAliasger K Salem - 2 Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa , Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Tissue engineering. Part A, Vol.23(19-20), pp.1169-1180
- DOI
- 10.1089/ten.TEA.2016.0556
- PMID
- 28463603
- PMCID
- PMC5653095
- NLM abbreviation
- Tissue Eng Part A
- ISSN
- 1937-3341
- eISSN
- 1937-335X
- Language
- English
- Date published
- 10/2017
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Orthodontics; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering
- Record Identifier
- 9984216702802771
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