Biomimetic Nanofibrous 3D Materials for Craniofacial Bone Tissue Engineering

Jacob M. Miszuk; Jue Hu; Hongli Sun

doi:10.1021/acsabm.0c00946

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Biomimetic Nanofibrous 3D Materials for Craniofacial Bone Tissue Engineering

Journal article

Open access

Peer reviewed

Biomimetic Nanofibrous 3D Materials for Craniofacial Bone Tissue Engineering

Jacob M. Miszuk, Jue Hu and Hongli Sun

ACS applied bio materials, Vol.3(10), pp.6538-6545

10/19/2020

DOI: 10.1021/acsabm.0c00946

PMCID: PMC7641339

PMID: 33163910

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https://www.ncbi.nlm.nih.gov/pmc/articles/7641339View

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Abstract

The repair of large bone defects using biomaterials-based strategies has been a significant challenge because of the complex characteristics required for tissue regeneration, especially in the craniofacial region. Tissue engineering strategies aimed at the restoration of function face challenges in material selection, synthesis technique, and choice of bioactive factor release in combination with all aforementioned facets. Biomimetic nanofibrous (NF) scaffolds are attractive vehicles for tissue engineering because of their ability to promote endogenous bone regeneration by mimicking the shape and chemistry of natural bone extracellular matrix (ECM). To date, several techniques for generation of biomimetic NF scaffolds have been discovered, each possessing several advantages and drawbacks. This spotlight highlights two of the more popular techniques for biomimetic NF scaffold synthesis, electrospinning and thermally induced phase separation (TIPS), covering development from inception in each technique as well as discussing the most recent innovations in each fabrication method.

Details

Title: Subtitle: Biomimetic Nanofibrous 3D Materials for Craniofacial Bone Tissue Engineering
Creators: Jacob M. Miszuk - University of Iowa
Jue Hu - University of Iowa
Hongli Sun - University of Iowa
Resource Type: Journal article
Publication Details: ACS applied bio materials, Vol.3(10), pp.6538-6545
DOI: 10.1021/acsabm.0c00946
PMID: 33163910
PMCID: PMC7641339
NLM abbreviation: ACS Appl Bio Mater
ISSN: 2576-6422
eISSN: 2576-6422
Grant note: DOI: 10.13039/100000072, name: National Institute of Dental and Craniofacial Research, award: R01DE029159, R03DE027491, T90DE023520; DOI: 10.13039/100008893, name: University of Iowa
Language: English
Date published: 10/19/2020
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Craniofacial Anomalies Research Center; Oral and Maxillofacial Surgery; Dental Research
Record Identifier: 9984367618602771

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