Journal article
Biophysical Model of an Auditory Nerve Fiber With a Novel Adaptation Component
IEEE transactions on biomedical engineering, Vol.56(9), pp.2177-2180
09/01/2009
DOI: 10.1109/TBME.2009.2023978
PMID: 19497810
Abstract
Recent data from feline auditory nerve fibers (ANFs) indicate that electrically stimulated fibers can undergo large degrees of rate adaptation to pulse-train stimuli using pulse rates within the range used by clinical auditory prostheses. However, the application of Hodgkin-Huxley-type models does not produce such adaptation, which occurs over time periods on the order of 100 ms. We describe our development of a computational ANF axon model that incorporates a time-changing external potassium concentration ([K+](ext)) that depends on potassium currents produced by active nodal channel activity. This relatively simple and computationally tractable approach produces poststimulus time histograms that are similar to experimental (cat) data. Furthermore, this mechanism could be easily incorporated into other models to produce much more realistic estimates of the neural coding produced by repeated electric stimulation.
Details
- Title: Subtitle
- Biophysical Model of an Auditory Nerve Fiber With a Novel Adaptation Component
- Creators
- Jihwan Woo - University of IowaCharles A. Miller - University of IowaPaul J. Abbas - University of Iowa
- Resource Type
- Journal article
- Publication Details
- IEEE transactions on biomedical engineering, Vol.56(9), pp.2177-2180
- Publisher
- IEEE
- DOI
- 10.1109/TBME.2009.2023978
- PMID
- 19497810
- ISSN
- 0018-9294
- eISSN
- 1558-2531
- Number of pages
- 4
- Grant note
- R01-DC006478 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01DC006478 / NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Deafness & Other Communication Disorders (NIDCD)
- Language
- English
- Date published
- 09/01/2009
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984383890902771
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