Biophysical attributes of an in vitro spinal cord surrogate for use in developing an intradural neuromodulation system

M Howard; M Utz; T Brennan; B Dalm; S Viljoen; J Kanwal; G Gillies

doi:10.1063/1.3642976

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Biophysical attributes of an in vitro spinal cord surrogate for use in developing an intradural neuromodulation system

Journal article

Peer reviewed

Biophysical attributes of an in vitro spinal cord surrogate for use in developing an intradural neuromodulation system

M Howard, M Utz, T Brennan, B Dalm, S Viljoen, J Kanwal and G Gillies

Journal of applied physics, Vol.110(7), pp.074701-074701-5

10/04/2011

DOI: 10.1063/1.3642976

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Abstract

We have developed a spinal cord surrogate for use in testing a pial-surface spinal cord stimulator. Our surrogate is of a commercially available silicone mix, has an oval cross-sectional area that matches that of actual human spinal cord at the lower thoracic level, and has measured values of durometer A=(10.96±1.68), durometer O=(14.76±1.48), and durometer OO=(50.24±2.65). These correspond to model-inferred elastic moduli of 0.41 to 0.44 MPa, which match well with the existing low-strain rate measurements of ex vivo human spinal cord. Upcoming applications for this surrogate in developmental studies of the new stimulator system are discussed.

Details

Title: Subtitle: Biophysical attributes of an in vitro spinal cord surrogate for use in developing an intradural neuromodulation system
Creators: M Howard - Department of Neurosurgery, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, Iowa 52242-1086, USA
M Utz - Department of Neurosurgery, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, Iowa 52242-1086, USA
T Brennan - Department of Neurosurgery, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, Iowa 52242-1086, USA
B Dalm - Department of Neurosurgery, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, Iowa 52242-1086, USA
S Viljoen - Department of Neurosurgery, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, Iowa 52242-1086, USA
J Kanwal - Department of Neurosurgery, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, Iowa 52242-1086, USA
G Gillies - Department of Neurosurgery, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, Iowa 52242-1086, USA
Resource Type: Journal article
Publication Details: Journal of applied physics, Vol.110(7), pp.074701-074701-5
Publisher: American Institute of Physics
DOI: 10.1063/1.3642976
ISSN: 0021-8979
eISSN: 1089-7550
Date published: 10/04/2011
Academic Unit: Otolaryngology; Anesthesia; Neurology; Neurosurgery; Iowa Neuroscience Institute
Record Identifier: 9984020870402771

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