Biospecimens and Molecular and Cellular Biomarkers in Aneurysmal Subarachnoid Hemorrhage Studies: Common Data Elements and Standard Reporting Recommendations

Sherry H-Y Chou; R Loch Macdonald; Emanuela Keller; Unruptured Intracranial Aneurysms and SAH CDE Project Investigators

doi:10.1007/s12028-019-00725-4

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Biospecimens and Molecular and Cellular Biomarkers in Aneurysmal Subarachnoid Hemorrhage Studies: Common Data Elements and Standard Reporting Recommendations

Journal article

Peer reviewed

Biospecimens and Molecular and Cellular Biomarkers in Aneurysmal Subarachnoid Hemorrhage Studies: Common Data Elements and Standard Reporting Recommendations

Sherry H-Y Chou, R Loch Macdonald, Emanuela Keller and Unruptured Intracranial Aneurysms and SAH CDE Project Investigators

Neurocritical care, Vol.30(Suppl 1), pp.46-59

06/2019

DOI: 10.1007/s12028-019-00725-4

PMCID: PMC7888262

PMID: 31144274

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Abstract

Development of clinical biomarkers to guide therapy is an important unmet need in aneurysmal subarachnoid hemorrhage (SAH). A wide spectrum of plausible biomarkers has been reported for SAH, but none have been validated due to significant variabilities in study design, methodology, laboratory techniques, and outcome endpoints. A systematic review of SAH biomarkers was performed per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The panel's recommendations focused on harmonization of (1) target cellular and molecular biomarkers for future investigation in SAH, (2) standardization of best-practice procedures in biospecimen and biomarker studies, and (3) experimental method reporting requirements to facilitate meta-analyses and future validation of putative biomarkers. No cellular or molecular biomarker has been validated for inclusion as "core" recommendation. Fifty-four studies met inclusion criteria and generated 33 supplemental and emerging biomarker targets. Core recommendations include best-practice protocols for biospecimen collection and handling as well as standardized reporting guidelines to capture the heterogeneity and variabilities in experimental methodologies and biomarker analyses platforms. Significant variabilities in study design, methodology, laboratory techniques, and outcome endpoints exist in SAH biomarker studies and present significant barriers toward validation and translation of putative biomarkers to clinical use. Adaptation of common data elements, recommended biospecimen protocols, and reporting guidelines will reduce heterogeneity and facilitate future meta-analyses and development of validated clinical biomarkers in SAH.

United States

Biomarkers - metabolism

Vasospasm, Intracranial - etiology

National Library of Medicine (U.S.)

Prognosis

Humans

Mortality

Brain Ischemia - metabolism

Subarachnoid Hemorrhage - complications

Brain Ischemia - etiology

Intracranial Aneurysm - metabolism

Aneurysm, Ruptured - complications

Subarachnoid Hemorrhage - metabolism

Specimen Handling

National Institute of Neurological Disorders and Stroke (U.S.)

Microdialysis

Aneurysm, Ruptured - metabolism

Vasospasm, Intracranial - metabolism

Biomedical Research

Common Data Elements

Details

Title: Subtitle: Biospecimens and Molecular and Cellular Biomarkers in Aneurysmal Subarachnoid Hemorrhage Studies: Common Data Elements and Standard Reporting Recommendations
Creators: Sherry H-Y Chou - Departments of Critical Care Medicine, Neurology, and Neurosurgery, University of Pittsburgh School of Medicine, 3550 Terrace Street Suite 646, Pittsburgh, PA, 15261, USA. chouh@upmc.edu
R Loch Macdonald - Departments of Physiology and Surgery, University of Toronto, Toronto, Canada
Emanuela Keller - Neurocritical Care Unit, Department of Neurosurgery, UniversitätsSpital Zürich, Zurich, Switzerland
Unruptured Intracranial Aneurysms and SAH CDE Project Investigators
Contributors: Colin P Derdeyn (Contributor) - University of Iowa, Radiology
Resource Type: Journal article
Publication Details: Neurocritical care, Vol.30(Suppl 1), pp.46-59
DOI: 10.1007/s12028-019-00725-4
PMID: 31144274
PMCID: PMC7888262
NLM abbreviation: Neurocrit Care
ISSN: 1541-6933
eISSN: 1556-0961
Publisher: United States
Grant note: N/A / CHI Baylor St Luke's Medical Center HHSN271201200034C / NINDS NIH HHS HHSN271201200034C / NIDA NIH HHS K23 NS073806 / NINDS NIH HHS R21 NS113037 / NINDS NIH HHS N/A / Neurocritical Care Society
Language: English
Date published: 06/2019
Academic Unit: Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984070511502771

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